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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | A multicenter,prospective,randomized trial evaluating the X-stop interspinous process decompression system for the treatment of neurogenic intermittent claudication显示文摘 | James F Ken YH Charles AH | 2005 | Spine2005，30，12： | 1 |
| 5 | Biological variation of galectin-3 and soluble ST2 for chronic heart failure: implication on interpretation of test results显示文摘 | Wu AH Wians F Jaffe A | 2013 | American Heart Journal2013，165，6： | 1 |
| 6 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 7 | From left ventricular hypertrophy to congestive heart failure:management of hypertensive heart disease显示文摘 | Gradman AH Alfayoumi F | | 0，，05： | 1 |
| 8 | Evidence for a single gene effect causing polycystic ovaries and male pattern baldness 显示文摘 | Carey AH Chan KL Short F | 1993 | Clin Endoerinol (Oxf)1993，38，6： | 1 |
| 9 | Analysis of a novel class of predictive microbial growth models and application to coculture growth显示文摘 | Posehet F Vereecken KM Geeraerd AH | 2005 | International Journal of Food Microbiology2005，100，： | 1 |
| 10 | Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromo- some abnormalities显示文摘 | Hopman AH Smedts F Dignef W | 2004 | J Pathol2004，202，1： | 1 |
| 11 | 14-day bactericidal activity of PA-824,bedaquiline,pyrazinamide,and moxifloxacin combinations:a randomised trial显示文摘 | Diacon AH Dawson R von Groote-Bidlingmaier F | | 0，，9846： | 1 |
| 12 | Potassium chan- nels in rat prostate epithelial cells 显示文摘 | ] Ouadid AH Van Coppenolle F Le Bourhis X | 1999 | FEBS Lett1999，459，1： | 1 |
| 13 | Risk assessment on renal dysfunction caused by co-exposure to arsenic and cadmium using benchmark dose calculation in a Chinese population 显示文摘 | Hong F Jin TY Zhang AH | 2004 | Biometals2004，17，5： | 1 |
| 14 | A multicenter,prospective,randomized trial evaluating the XSTOP interspinous process decompression system for the treatment of neurogenic intermittent claudication显示文摘 | James F Ken YH Charles AH | 2005 | Spine2005，30，12： | 1 |
| 15 | Role of heart-type fatty acidbinding protein in early detection of acute myocardial infarction 显示文摘 | Ghani F Wu AH Graff L | 2000 | Clin Chem2000，46，5： | 1 |
| 16 | Case report of a pelvic-peritoneal tuberculosis presenting as an adnexial mass and mimicking ovarian cancer,and a review of the literature显示文摘 | Ilhan AH Durmusoglu F | 2004 | Infect Dis Obstet Gynecol2004，12，： | 1 |
| 17 | Trendsin cervical squamous cell Carcinoma incidencd in 13 European Coun-tries:changing risk and the effects of screening显示文摘 | Bray F Loos AH Mc Carron Cp etal | 2005 | Cancer Epidemiol Biomar Kers Prev2005，14，3： | 1 |
| 18 | From left ventricular hypertrophy to congestive heart failure : management of hypertensive heart disease显示文摘 | Gradman AH Mfayoumi F | 2006 | Prog Cardiovasc Dis2006，48，5： | 1 |
| 19 | Association between obesity and dental caries in a group of preschool children in Mexico显示文摘 | Vdzquez-Nava F Vdzquez-Rodriguez EM Saldivar-Gonzdlez AH | 2010 | J Public Health Dent2010，70，2： | 1 |
| 20 | Plasma A- and B-type nat- riuretic peptides: physiology, methodology and clinical use 显示文摘 | Boomsma F van den Meiracker AH | 2001 | CardiovascRes2001，51，3： | 1 |
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