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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | 临床试验数据共享声明国际医学期刊编辑委员会统一要求显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了1项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。迄今,应我们的反馈要求,ICMJE收到了很多来自个人和团体的意见。 | Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 4 | 临床试验数据共享声明显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了一项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。 | Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛 | 2017 | 中国医院院长2017，13，16： | 2 |
| 5 | Metal phthalocyanine-catalyzed lithium/thionyl chloride cells显示文摘 | Abraham K M Alamgir M Willstaedt E B | 1992 | Electrochim Acta1992，37，3： | 1 |
| 6 | The action of chromium on serum lipids and on atherosclerosis in cholesterol feed rabbits 显示文摘 | Abraham A S Brooks B A Eylath U | 1982 | Atherosclersis1982，42，： | 1 |
| 7 | InCl3-cata-lyzed regioselective opening of aziridines with heteroaro-matics显示文摘 | Yadav J S Reddy B V S Abraham S | 2002 | Tetrahedron Lett2002，43，8： | 1 |
| 8 | Management of Rheumatoid Arthritis: Rationale for the Use of Colloidal Metallic Gold显示文摘 | ABRAHAM G E HIMMEL P B | 1997 | Nutr Med1997，，7： | 1 |
| 9 | Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereos-elective properties显示文摘 | Graf B M Abraham I Eberbach N | 2002 | Anesthesiology2002，96，6： | 1 |
| 10 | Peritoneal dialysis for acute kidney injury显示文摘 | Cullis B Abdelraheem M Abrahams G | 2014 | Perit Dial Int2014，34，5： | 1 |
| 11 | Automatic design of hierarchical Takagi-Sugeno type fuzzy systems using evolutionary algorithms显示文摘 | Chen Y Yang B Abraham A | 2007 | IEEE Trans on Fuzzy Systems2007，15，3： | 1 |
| 12 | Centro-symmetric technique for measuring shear modulus, viscosity, and surface tension of spread monolayers显示文摘 | Miyano K Xu S Q | 1983 | Review of Scientific Instruments1983，54，2： | 1 |
| 13 | Effect of humidity and temperature on the DC breakdown of rob-rob and rob-plane gaps显示文摘 | Abraham A P Prabhakar B R | 1992 | IEEE Transactions on Electrical Insulation1992，27，2： | 1 |
| 14 | Role of the molecular absorbent recycling system(MARS)in the treatment of patients with acute exacerbation of chronic liver failure显示文摘 | Sorkine P Abraham R B Szold O | 2001 | Crit Care Med2001，29，7： | 1 |
| 15 | Cardiac effects of continuous and bilevel positive airway pressure for patients with heart failure and obstructive sleep apnea:a pilot study显示文摘 | Khayat RN Abraham WT Patt B | | 0，，6： | 1 |
| 16 | Extraction of nanocellulose fibrils from lignocellulosicfibres: A novel approach显示文摘 | Abraham E Deepa B Pothan L A | 2011 | Carbohydrate Polymers2011，86，4： | 1 |
| 17 | Polyaniline/carbon nanotube composites: starting with phenylamino functionalized carbon nanotubes 显示文摘 | PHILIP B XIE J N ABRAHAM J K | 2005 | Polymer bulletin2005，53，2： | 1 |
| 18 | Fundic gland polyps in familial adenomatous poluposis: neopasms with frequent somatic adenomatous polyposis coli gene alteration 显示文摘 | Abraham SC Nobukawa B Giardicllo FM | 2000 | Am J Pathol2000，157，： | 1 |
| 19 | Issues in pediatric palIiative care:Understanding families显示文摘 | Abraham S B David W K | | J Palliat Care0，2，3： | 1 |
| 20 | Effect of nanoplatelet aspect ratio on designed synthetic nanoplatelets 显示文摘 | WOONG J B SUN L Y ABRAHAM C | 2007 | Polymer2007，48，4： | 1 |
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