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| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | 不同灌溉和施肥水平对东尼罗河三角洲地区甜菜产量、品质及部分水分指标的影响(英文)显示文摘【目的】2008~2009、2009~2010年分别在埃及El-Sharkia省Zankalon研究站进行不同灌溉和氮肥水平对甜菜产量、品质及水分指标的影响试验。【方法】采用裂区设计,分别设3个灌溉处理即I1(60%田间持水量)、I2(80%田间持水量)和I3(100%田间持水量)和3个施肥处理即N1(50kgN/fed)、N2(70kgN/fed)和N3(90kgN/fed)。【结果】灌水处理I1的甜菜块根和糖产量最高、根径最大,其次为处理I2,处理I3的最低。随着灌溉水平的提高,甜菜块根长和蔗糖含量明显下降。当施用90kgN/fed氮肥,甜菜根长、根径、块根和糖产量明显提高,但糖分则有所降低。灌溉和施氮肥处理均对蔗糖纯度没有明显影响。3个灌溉处理I1、I2和I3的水分利用量分别为3579.7、3042.0和2504.0m2/fed,季节耗水量分别为58.12、52.06和47.29cm,而甜菜块根产量、糖产量的水分利用率分别为15.86、13.78、13.35kg块根/m3水和2.73、2.61and2.56kg糖/m3水。随着施氮水平的提高,获得一定甜菜根产量和糖产量,所需的实际耗水量和水分利用率也不断提高。在东尼罗河三角洲地区的甜菜平均季节作物系数为0.87。【结论】可在东尼罗河三角洲地区推荐使用Kc经验值来计算耗水量。 | Abd El-Razek A M Atta Y I Hassan A F | 2011 | 南方农业学报2011，42，8： | 7 |
| 3 | Enhanced hydrogen storage kinetics of LiBH4 in nanoporous carbon scaffolds显示文摘 | Gross A F Vajo J J Van Atta S L | 2008 | The Journal of Physical Chemistry C2008，112，14： | 1 |
| 4 | Polymeric structures as cold flow improvers for waxy residual fuel oil 显示文摘 | EI-Gamal I M Atta A M A1-Sabbagh A M | 1997 | Fuel1997，76，1415： | 1 |
| 5 | Evaluation of some medicinal plant extracts for antidiarrhoeaI activity 显示文摘 | Atta A H Mouneir S M | 2005 | Phytother Res2005，19，6： | 1 |
| 6 | Comparative Histology of the Renal Unit and the Meso-Nephric Duct of Some Freshwater Teleostean Kidneys显示文摘 | Abdel-Hamid M E Atta F A | 1987 | Delta J Sci Tanta Univ1987，11，： | 1 |
| 7 | Antidiarrhoeal activity of some Egyptian medicinal plant extracts 显示文摘 | Atta A H Mouneir S M | 2004 | J Ethnopharmacol2004，92，30： | 1 |
| 8 | The antinociceptive effect of some Egyptian medicinal plant extracts 显示文摘 | Atta A H EL-Sooud K A | 2004 | J Ethnopharmacol2004，95，23： | 1 |
| 9 | Antifungal Mac- rodiode Production By Streptomyces albidoflavus-143: Fermentation, Purification and Biological Activities 显示文摘 | Honssam M Atta E1-Sehrawi M H Bahobail A S | 2011 | Journal of American Sci- ence2011，7，3： | 1 |
| 10 | Crosslinked cinnamoyloxyethyl methacrylate and isooctyl acrylate copolymers as oil sorbers显示文摘 | Atta Ayman M El-Ghazawy Rasha A M Farag Reem K | | 0，，07： | 1 |
| 11 | Depletion of trimethoprim and sulphadiazine from eggs of laying hens receiving trimethoprim/sulphadiazine combination显示文摘 | ATTA A H SAMIAA E Z | 2001 | Food Control2001，12，： | 1 |
| 12 | 2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis显示文摘 | Berkun Y Abou Atta I Rubinow A | 2007 | J Rheumatol2007，34，8： | 1 |
| 13 | Swelling and network parameters of high oil-absorptive network based on 1- octene and isodecyl acryl ate copolymers 显示文摘 | ATTA A M AMDT K F | 2005 | J Appl PolymSci2005，97，： | 1 |
| 14 | Crosslinked poly(octadecene-alt-maleic anhydride) copolymers as crude oil sorbers显示文摘 | ATTA A M EL-HAMOULY S H ALSABAGH A M | 2007 | J Appl Polym Sci2007，105，4： | 1 |
| 15 | Surface and thermodynamic parameters of polymeric surfactants form recycled poly (ethylene terephthalate) 显示文摘 | ATTA A M | 2007 | Polymer International2007，56，8： | 1 |
| 16 | Kinetics of cellgrowth and cyclosporin A production by Tolypocladiuminflatum when scaling up from shake flask to bioreactor 显示文摘 | El Enshasy H Abdel Fattah Y Atta A | 2008 | J Microbiol Biotechnol2008，18，1： | 1 |
| 17 | Total mercury distribution in different tissues of six species of freshwater fish from the Kpong hydroelectric reservoir in Ghana 显示文摘 | Atta A Voegborlo R B Agorku E S | 2012 | Environmental Monitoring and Assessment2012，184，5： | 1 |
| 18 | Metabolic biomarkers related to energy metabolism in Saudi autistic children 显示文摘 | A1-Mosalem OA E1-Ansary A Attas O | 2009 | Clin Biochem2009，42，1011： | 1 |
| 19 | Antimicrobial resist- ance in clinical isolates of Staphylococcus aureus from bovine and human sources in Egypt显示文摘 | El-Jakee J K Atta N S Samy A A | 2011 | Global Vet2011，，7： | 1 |
| 20 | Polymeric structures as cold flow improvers for waxy residual fuel oil显示文摘 | EI-Gamal I M Atta A M AI-Sabbagh A M | 1997 | Fuel1997，76，1415： | 1 |
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