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| 1 | PD-L1在不同乳腺癌亚型及分期病例中的表达及其肿瘤内异质性:245例原发和40例转移癌的研究显示文摘肿瘤组织中PD—L1表达与多种恶性肿瘤免疫逃逸有关,包括三阴型乳腺癌,通过PD—L1标记有助于选择适合于PD—I/PD—L1抑制剂治疗患者。作者采用组织芯片技术对各种组织学形态的乳腺癌进行PD—L1表达和研究,以探讨其在原发和转移性乳腺癌中的异质性,研究病例包括245例原发性乳腺癌和40例转移性乳腺癌(淋巴结转移及远处转移各20例),瘤细胞PD—L1膜着色细胞≥1%定义为阳性。 | Dill E A Gru A A Atkins K A.Atkins 王婷 余英豪 | 2017 | 临床与实验病理学杂志2017，33，10： | 17 |
| 2 | P16免疫染色可以提高子宫平滑肌肿瘤的组织学分类显示文摘 | Atkins K A Arronte N Darus C J 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，1： | 13 |
| 3 | Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity显示文摘AIM: To investigate the role of type-I left-right bicuspid aortic valve(LR-BAV) hemodynamic stresses in the remodeling of the thoracic ascending aorta(AA) concavity, in the absence of underlying genetic or structural defects.METHODS: Transient wall shear stress(WSS) profiles in the concavity of tricuspid aortic valve(TAV) and LR-BAV AAs were obtained computationally. Tissue specimens excised from the concavity of normal(nondilated) porcine AAs were subjected for 48 h to those stress environments using a shear stress bioreactor. Tissue remodeling was characterized in terms of matrix metalloproteinase(MMP) expression and activity via immunostaining and gelatin zymography.RESULTS: Immunostaining semi-quantification results indicated no significant difference in MMP-2 and MMP-9 expression between the tissue groups exposed to TAV and LR-BAV AA WSS(P = 0.80 and P = 0.19, respectively). Zymography densitometry revealed no difference in MMP-2 activity(total activity, active form and latent form) between the groups subjected to TAV AA and LR-BAV AA WSS(P = 0.08, P = 0.15 and P = 0.59, respectively).CONCLUSION: The hemodynamic stress environment present in the concavity of type-I LR-BAV AA does not cause any significant change in proteolytic enzyme expression and activity as compared to that present in the TAV AA. | Samantha K Atkins Alison N Moore Philippe Sucosky | 2016 | World Journal of Cardiology2016，8，1： | 3 |
| 4 | Highaccuracy algorithms for computational aeroacoustics 显示文摘 | Lockard D P Brentner K S Atkins H L | 1995 | J AIAA1995，33，： | 2 |
| 5 | Leaf respiration of show gum in light and dark interaction between temperature and irradiance 显示文摘 | ATKIN O K EVANS J R BALL M C | 2000 | Plant Physiology2000，122，： | 1 |
| 6 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 7 | New Developments in Low Pressure SMC显示文摘 | Atkins K E | 1996 | Modern Plastics Internetional1996，，3： | 1 |
| 8 | QoS negotiation in real-time systems and its applications to automated flight control 显示文摘 | Atdelzater T F Atkins E M Shin K G | 2000 | IEEE Trans on Computers2000，49，11： | 1 |
| 9 | Analysis of cyromazine in poultry feed using the QuEChERS method coupled with LC-MS/ MS显示文摘 | XIA K ATKINS J FOSTER C | 2010 | Journal of Agricultural and Food Chemistry2010，58，10： | 1 |
| 10 | Three-dimensional imaging for virtual assessment and treatment simulation in orthognathic sur- gery 显示文摘 | Caloss R Atkins K Stella J P | 2007 | Oral Maxillofac Surg Clin N Am2007，19，3： | 1 |
| 11 | Transmit-signal de- sign and processing strategies for sonar target phase mea- surement显示文摘 | ATKINS P COLLINS T FOOTE K | 2007 | IEEE Journal of Selected Topics in Signal Processing2007，1，1： | 1 |
| 12 | On the role of Cs, Cl and subsurface O in promoting selectivity in Ag/a- Al2O3 catalysed oxidation of ethene to ethene epoxide显示文摘 | Atkins M Couves J Waugh K C | 2005 | J Catal2005，235，1： | 1 |
| 13 | The determination of minor and trace element associations in coal using a sequential microwave digestion procedure显示文摘 | Laban K L Atkin B P | 1999 | International Journal of Coal Geology1999，41，： | 1 |
| 14 | A novel five-transmembrane hematopoietic stem cell antigen : isolation, characterization, and molecular cloning 显示文摘 | Miraglia S Godfrey W Yin A H Atkins K Warnke R Holden J T | 1997 | Blood1997，90，： | 1 |
| 15 | Thermal acclimation and the dynamic re- sponse of plant respiration to temperature显示文摘 | Atkin O K Tjoelker M G | 2003 | Trends in Plant Sci- ence2003，8，7： | 1 |
| 16 | High thermal acclimation potential of both photosynthesis and respiration in two lowland Plantago species in contrast to an alpine congeneric 显示文摘 | ATKIN O K SCHEURWATER I PONS J L | 2006 | Global Change Biology2006，12，： | 1 |
| 17 | The impact of epidermal melanin on objective measurements of human skin colour显示文摘 | Alaluf S Atkins D Barrett K | 2002 | Pigment Cell Res2002，15，： | 1 |
| 18 | Using bi- omarkers as objective standards in the diagnosis of cervi- cal biopsies显示文摘 | Galgano M T Castle P E Atkins K A | 2010 | Am J Surg Pathol2010，34，8： | 1 |
| 19 | Patient characteristics and treatment outcome in functional anorectal pain显示文摘 | ATKIN G K SULIMAN A VAIZEY C J | 2011 | Dis Colon Rectum2011，54，： | 1 |
| 20 | LAU-0901,a novel plate-let-activating factor receptor antagonist,confers enduring neuropro-tection in experimental focal cerebral ischemia in the rat显示文摘 | Belayev L Khoutorova L Atkins K | 2009 | BrainRes2009，1253，： | 1 |
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