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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 3 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 4 | Modern approaches to incompatible kidney transplantation显示文摘The presence of human-leukocyte antigen(HLA)-antibodies and blood group incompatibility remain a large barrier to kidney transplantation leading to increased morbidity and mortality on the transplant waiting list.Over the last decade a number of new approaches were developed to overcome these barriers.Intravenous immunoglobulin(IVIG) remains the backbone of HLA desensitization therapy and has been shown in a prospective,randomized,placebo controlled trial to improve transplantation rates.Excellent outcomes with the addition of rituximab(anti-B cell) to IVIG based desensitization have been achieved.There is limited experience with bortezomib(anti-plasma cell) and eculizumab(complement inhibition) for desensitization.However,these agents may be good adjuncts for patients who are broadly sensitized with strong,complement-fixing HLA antibodies.Excellent short and long-term outcomes have been achieved in ABO incompatible transplantation with the combination of antibody removal,B cell depletion,and pre-transplant immunosuppression.Kidney paired donation has emerged as a reasonable alternative for programs who cannot provide desensitization or in conjunction with desensitization.Future therapies directed toward cytokines that alter B cell proliferation are under investigation. | Patarapha Wongsaroj Joseph Kahwaji Ashley Vo Stanley C Jordan | 2015 | World Journal of Nephrology2015，4，3： | 3 |
| 5 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 6 | Spratt the evolutionary history of methicillin-resistant Staphylococcus anreus (MRSA)显示文摘 | Enright D Ashley Robinson | 2002 | PNAS2002，99，11： | 1 |
| 7 | Revision of the American Joint Committee on Cancer staging system for breast cancer显示文摘 | Singletary SE Allred C Ashley P | 2002 | J Clin Oncol2002，20，17： | 1 |
| 8 | Pro-poor tourism: putting poverty at the heart of the tourism agenda 显示文摘 | Ashley C Boyd C Goodwin H | 2000 | ODI Natural Resource Perspectives2000，51，6： | 1 |
| 9 | A multi-plasmid approach to preparing large libraries of polyketides显示文摘 | Ashley G Hutchinson C R | 1999 | Proc Natl Acad Sci USA1999，96，11： | 1 |
| 10 | Revision of the American Joint Committee on Cancer staging system for breast cancer显示文摘 | Singletary SE Mired C Ashley P | 2002 | J Clin Oncol2002，20，17： | 1 |
| 11 | Intraoperative local an- aesthesia for reduction of postoperative pain following general an- aesthesia for dental treatment in children and adolescents显示文摘 | Parekh S Gardener C Ashley PF | 2014 | Co- chrane Database Syst Rev2014，12，00： | 1 |
| 12 | IL-17-producing human peripheral regulatory T cells retain suppressive function显示文摘 | Beriou G Costantino C M Ashley C W | 2009 | Blood2009，113，18： | 1 |
| 13 | Triplet repeat expansion mutations:the example of fragile X syndrome显示文摘 | Warren S T Ashley C T Jr | 1995 | Annu Rev Neurosci1995，18，： | 1 |
| 14 | Discrimination of hydrothermally altered rocks and unaltered rocks in visible and near infrared multi- spectral images显示文摘 | ROWAN L C GOETZ A F H ASHLEY R P | 1977 | Geophysics1977，42，3： | 1 |
| 15 | Urachal anomalies:a lon- gitudinal study of uraehal remnants in children and adults显示文摘 | Ashley R A Inman B A Routh J C | 2007 | JUrol2007，178，4： | 1 |
| 16 | Identifying coronary artery disease in men with type 2 diabetes:osteoprotegerin,pulse wave velocity,and other biomarkers of cardiovascular risk 显示文摘 | Davenport C Ashley DT O'Sullivan EP | 2011 | J Hypertens2011，29，12： | 1 |
| 17 | Determination of 10 carcinogenic polyeyclic aromatic hydrocarbons in mainst-ream cigarette smoke显示文摘 | Ding Y S Ashley D L Watson C H | 2007 | J Agri & Food Chem2007，55，： | 1 |
| 18 | Electrostatically mediated liposome fusion and lipid exchange with a nanoparticle-supported bilayer for control of surface charge, drug containment, and deliver 显示文摘 | Liu J Jiang X Ashley C | 2009 | J Am Chem Soc2009，131，22： | 1 |
| 19 | Sequence and genome organization of a human small round-structured(Norwalk like)virus显示文摘 | Lambden P R Caul E O Ashley C R | 1993 | Science1993，259，5094： | 1 |
| 20 | On Radar Detection and Direction Finding using Sparse Arrays显示文摘 | Ashley F Engdahl C Sunnergren P | | IEEE Transactions on Aerospace and Electronic Systems0，43，4： | 1 |
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