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| 1 | Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells显示文摘 | Charles N Ozawa T Squatrito M Bleau AM Brennan CW Hambardzumyan D Holland EC. | 2010 | 中国神经肿瘤杂志2010，8，1： | 24 |
| 2 | Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children显示文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. | MS El-Raziky M El-Hawary G Esmat AM Abouzied N El-Koofy N Mohsen S Mansour A Shaheen M Abdel Hamid H El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，12： | 4 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | Problem based learning approaches to the technology education of physical therapy students显示文摘 | Castro-Sánchez AM Encarnación M Aguilar-Ferrándiz M | 2012 | Med Teach2012，34，1： | 1 |
| 5 | Urinary 8-hydroxy-2' -deoxyguanosine as a biological marker of in vivo oxidative DNA damage显示文摘 | Shigenaga M K Gimeno C J Ames B N | 1989 | Proc Natl Aead Sci USA1989，86，24： | 1 |
| 6 | Lowlevel laser therapy and myofacial pain dysfunction syndrome:a randomized controlled clinical trial显示文摘 | Shirani AM Gutknecht N Taghizadeh M | 2009 | Lasers Med Sci2009，24，5： | 1 |
| 7 | Anti-EDRF effect of tumor necrosis factor in isolated perfused cat carotid arteries显示文摘 | Aoky N Siegfried M Lefer AM | 1989 | Am J Physiol1989，256，： | 1 |
| 8 | Occupational asthma in the aluminum smelters of Australia and New Zealand: 1991-2006 显示文摘 | Donoghue AM Frisch N Ison M | 2011 | Am J Ind Med2011，54，3： | 1 |
| 9 | Oxidants, antioxidants, and the degeneration disease of the aging显示文摘 | Ames B N Shigenaga M K Hagen T M | 1993 | Pro Natl Acad Sci USA1993，90，： | 1 |
| 10 | Oxidative damage and mitochondrial decay in aging显示文摘 | Shigenaga M K Hagen T M Ames B N | 1994 | Proc Nat Acad Sci USA1994，91，10： | 1 |
| 11 | Gas phase oxidants of cite smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma : Protective effects of ascorbic acid 显示文摘 | FREI B FOR7I'E T M AMES B N | 1991 | Biochem J1991，277，： | 1 |
| 12 | Surface electromagnetic waves in optics显示文摘 | Bonch-Bruevich AM Libenson M N Makin V S | 1992 | Optical En?gineering1992，31，4： | 1 |
| 13 | Exopolysaccharides produced by intestinal Bifidobacteriurn strains act as fermentable substrates for human intestinal bac- teria显示文摘 | Salazar N Gueimonde M Hem Ndez-Barranco AM | 2008 | Appl & Environ Microbiol2008，74，15： | 1 |
| 14 | Muhiwavelength optical intrinsic signal imaging of cortical spreading depression显示文摘 | Ba AM Guiou M Pouration N | 2002 | J Neurophysiol2002，88，5： | 1 |
| 15 | Oxidants, antioxidants, and the degenerative diseases of aging 显示文摘 | Ames B N Shigenaga M K Hagen T M | 1993 | Proc Natl Acad Sci USA1993，90，17： | 1 |
| 16 | OxyR, a positive regulator of hydrogen peroxideinducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins 显示文摘 | CHRISTMAN M F STORZ G AMES B N | 1989 | PNAS1989，86，10： | 1 |
| 17 | Potential influence of interleukin-1 receptor antagonist gene polymorphism on knee osteoarthritis risk显示文摘 | Swel am M Mahmoud MS Samy N | | 0，，： | 1 |
| 18 | Nanoplasmonics for dual-molecule release through nanopores in the membrane of red blood cells显示文摘 | Delcea M Sternberg N Yashchenok AM | 2012 | ACS Nano2012，6，5： | 1 |
| 19 | Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa 显示文摘 | Umegaki-Arao N Pasmooij AM Itoh M | 2014 | Sci Transl Med2014，6，264： | 1 |
| 20 | Identification of a novel coronavirus in patients with severe acute respiratory syndrome显示文摘 | Gunther S Preiser W van der Weft S Brodt HR Becker S Rabenau H Panning M Kolesnikova L Fouchier RA Berger A Burguiere AM Cinatl J Eickmann M Escriou N Grywna K Kramme S Manuguerra JC Muller S Rickerts V Sturmer M Vieth S Klenk HD Osterhaus AD Schmitz H Doerr HW | 2003 | N Engl J Med2003，348，： | 1 |
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