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| 1 | Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children显示文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. | MS El-Raziky M El-Hawary G Esmat AM Abouzied N El-Koofy N Mohsen S Mansour A Shaheen M Abdel Hamid H El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，12： | 4 |
| 2 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | Association of nonalcoholic fatty liver disease with insulin resistance显示文摘 | Marehesini G Brizi M Morselli-Lsbate AM | 1999 | Am J Med1999，107，5： | 1 |
| 5 | Characterisation of backcross generations obtained under field conditions from oilseed rape-wild radish F1 interspecific hybrids: an assessment of transgene dispersal 显示文摘 | Chevre AM Eber F Baranger A Hureau G Barret P Picault H Renard M | 1998 | Theor Appl Genet1998，97，： | 1 |
| 6 | Clinical I utility of liquid2basod cytology for the characterization and management of endometfial polyps in postmenopausal age显示文摘 | Fambrini M Buccolieroy AM Bargelli G et a1 | 2008 | Int J Gynecol Cancer2008，18，2： | 1 |
| 7 | Association of nonalcoholic fatty liver disease with insulin resistance 显示文摘 | Marchesini G Brizi M Morselli - Labate AM | 1999 | Am J Med1999，107，5： | 1 |
| 8 | Association of non-alcoholic fatty liver disease with insulin resistance显示文摘 | Marchesini G Brizi M Morselli Labate AM | 1999 | AM J Med1999，107，5： | 1 |
| 9 | Method of delivery and pregnancy outcomes in Asia:the WHO global survey on maternal and perinatal health显示文摘 | Lumbiganon P Laopaiboon M Gülmezoglu AM | | 0，，9713： | 1 |
| 10 | The parafascicular nucleus and two-way active avoidance:effects of electrical stimulation and electrode implantation显示文摘 | Guillazo-Blanch G Vale-Martinez AM Marti-Nicolovius M | 1999 | Exp Brain Res1999，129，4： | 1 |
| 11 | Association of nonalcoholic fatty liver disease with insuliu resistance显示文摘 | Marchesini G Brizi M Morselli-Labate AM | 1999 | Am J Med1999，107，5： | 1 |
| 12 | N-acetyl-cyste- ine treatment improves insulin sensitivity in women with polycystic ovary syndrome 显示文摘 | Fulchesu AM Ciampelli M Muzj G | 2002 | Fertility and Sterility2002，77，6： | 1 |
| 13 | Association of nonalcoholic fatty liver disease with insulin resistance显示文摘 | Marehesini G Brizi M Morselli-Labate AM | 1999 | Am J Med1999，107，5： | 1 |
| 14 | Collagen-derived markers of bone metabolism in osteogenesis imperfecta显示文摘 | Lund AM Hansen M Kollerup G | 1998 | Acta Paediatr1998，87，11： | 1 |
| 15 | Association of nonalcoholic fatty liver disease with insulin resistance显示文摘 | Brizi M Morselli Labate AM | 1999 | Am J Med1999，107，5： | 1 |
| 16 | Neoplastic transformation of oral lichen: case report and review of the literature 显示文摘 | Abbate G Foscolo AM Gallotti M | 2006 | Acta Otorhinolaryngol Ital2006，26，1： | 1 |
| 17 | Pulmonary endarterectomy:the treatment of choice for chronic thromboembolic pulmonary hypertension显示文摘 | Armini AM Zanotti G Vigano M | 2005 | Ital Heart J2005，6，10： | 1 |
| 18 | Association of nonalcoholic fatty liver disease with insulin resistance显示文摘 | Marchesini G Brizi M Morselli-Labate AM | 1999 | Am J Med1999，107，： | 1 |
| 19 | Incidence of secondary Helicobacter pylori resistance to antibiotics in treatment failures after 1-week proton pump inhibitor-based triple therapies:a prospective study显示文摘 | Pilotto AM Franceschi M Rassu G | 2000 | Dig Liver Dis2000，32，： | 1 |
| 20 | A prospec- tive randomized study with a 5-year minimum follow-up evaluation of transanal endoscopic microsurgery versus laparoscopic total mesorectal excision after neoadjuvant therapy显示文摘 | Lezoche G Baldarelli M Paganini AM | 2008 | Surg Endosc2008，22，2： | 1 |
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