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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Correction of early cognitive disorders in school-age children operated under total intravenous anaesthesia显示文摘 | Ovezov AM Lobov MA Panteleeva MV | 2012 | Anesteziol Reanimatol2012，3，： | 1 |
| 3 | Does breast cancer start in the womb? 显示文摘 | Soto AM Vandenberg LN Maffini MV | 2008 | Basic Cfin Pharmacol Toxicol2008，102，： | 1 |
| 4 | Gemcit- abine and cisplatin salvage regimen in heavily pretreated meta- static breast cancer: a Brazilian experience 显示文摘 | de Lima Arat:jo LH Moitinho MV Silva AM | 2011 | Med Oncol2011，28，1： | 1 |
| 5 | Correction of early cognitive disorders in school-age children operated under total intravenous anaesthesia显示文摘 | Ovezov AM Lobov M Panteleeva MV etal | 2012 | Anesteziol Reanimatol2012，3，： | 1 |
| 6 | Correction of early cognitive disorders in school-age children operated under total intravenous anesthesia显示文摘 | Ovezov AM Lobov MA Panteleeva MV | 2012 | Anesteziol Reanimatol2012，，3： | 1 |
| 7 | Analysis of the valproic acid-meropenem interaction in hospitalised patients显示文摘 | Diaz-Pallar6s MV Silveira ED Diaz AM | 2012 | Neurologia2012，27，1： | 1 |
| 8 | Sex and ethnic differences in the association of ASPN,CALM1 ,COL2A1 ,COMP and FRZB with genetic susceptibility to osteoarthritis of knee 显示文摘 | Valdes AM Loughlin J Oene MV | 2007 | Arthritis Rheum2007，1，： | 1 |
| 9 | The relationship of stress and anxiety with chronic periodontitis显示文摘 | Vettore MV Leito AT Monteiro Da Silva AM | 2003 | J Clin Periodontol2003，30，5： | 1 |
| 10 | NAFLD, NASH and liver canc- er显示文摘 | Michelotti GA Machado MV Diem AM | 2013 | Nat Rev Gastroenterol Hepatol2013，10，11： | 1 |
| 11 | Interventional techniques:evidence-based practice guidelines in the management of chronic spinal pain显示文摘 | Trescot AM Datta S | 2007 | Pain Physician2007，10，： | 1 |
| 12 | Monitoring of intense neuromuscular blockade in a pig model 显示文摘 | Madsen MV Donatsky AM Jensen BR | 2014 | J Clin Monit Comput2014，28，4： | 1 |
| 13 | The effect of chromium pipolinate on the liver levels of trace elements显示文摘 | Aguclar MV Jorge AM | 1995 | Nutr Hosp1995，10，6： | 1 |
| 14 | IL-17contributes to angiogenesis in rheumatoid arthritis显示文摘 | Pickens SR Volin MV Mandelin AM II | 2010 | Immunol2010，184，： | 1 |
| 15 | Group-specific differentiation between high-and low-risk human papillomavirus genotypes by general primer-mediated PCR and two cocktails of oligonucleotide probes显示文摘 | Jacobs MV de Roda Husman AM van Brule AJ | 1995 | J Clin Microbiol1995，33，4： | 1 |
| 16 | Safety and clinical finding of BiPAP utilization in children 20kg or less for asthma exacerbations显示文摘 | Williams AM Abramo TJ Shah MV | 2011 | Intensive care medicine2011，37，8： | 1 |
| 17 | Neuroprotective effect of individual ginsenosides on astrocytes primary culture 显示文摘 | Lopez MV Cuadrado MP Ruiz-Poveda OM Del Fresno AM Accame ME | 2007 | Biochim Biophys Acta2007，1770，9： | 1 |
| 18 | Axonal Loss After Traumatic Ophtic Neuropathy Documented by Optical Coberence Tomography显示文摘 | Felipe AM Frederico CM Roberto MV | 2003 | Am J Ophthalmol2003，135，3： | 1 |
| 19 | Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain 显示文摘 | BOSWELL MV TRESCOT AM DATTA S | 2007 | Pain Physician2007，10，1： | 1 |
| 20 | Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain 显示文摘 | Boswell MV Trescot AM Datta S | 2007 | Pain Physician2007，10，： | 1 |
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