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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Postintervention serum TSH levels may be useful to diffenrentiate patients who should undergo levothyroxine suppressive therapy after thyroid surgery for multinodular goiter in a region with moderate iodine deficiency显示文摘 | Rotondi M Amato G Del Buono A | 2000 | Thyroid2000，10，12： | 1 |
| 3 | In situ detection of tree root distribution and biomass by multi-electrode resistivity imaging显示文摘 | Amato M Basso B Celano G | 2008 | Tree physiology2008，28，10： | 1 |
| 4 | Environmental risk factors and allergic bronchial asthma显示文摘 | D'Amato M Liccardi G D'Amato M | 2005 | Clin Exp Allergy2005，35，9： | 1 |
| 5 | Topical application of isosorbide dinitrate in patients with persistent constipation after pull-through surgery for Hirschsprung's disease显示文摘 | Messina M Amato G Meucci D | 2007 | Eur J Pediatr Surg2007，17，1： | 1 |
| 6 | Update on the biology and therapy of gastrointestinal stromal tumors 显示文摘 | D' AMATO G STEINERT D M MCAULIFFE J C | 2005 | Cancer Control2005，12，1： | 1 |
| 7 | Input-output finite-time stabilization of linear systems显示文摘 | Amato F Ariola M Cosentino C Tommasi G D | 2010 | Automatica2010，46，9： | 1 |
| 8 | lntraoperative brachytherapy following thoracoscopic wedge resection of stage I lung cancer显示文摘 | d'Amato TA Galloway M Szydlowaki G | 1998 | Chest1998，114，4： | 1 |
| 9 | Environmental risk factors and allergic bronchial asthma 显示文摘 | D'AMATO G LICCARDI G D'AMATO M | 2005 | Clin Exp Allergy2005，35，9： | 1 |
| 10 | Exchanges-spring behavior of hard/soft magnetic multilayers:optimization stuay of the nanostructure显示文摘 | AMATO M RETTORI A PIN M G | 2000 | Physics B2000，275，13： | 1 |
| 11 | Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles显示文摘 | Amato G Conte M Mazziotti G | 2003 | Obstet Gynecol2003，101，6： | 1 |
| 12 | The Role of Outdoor Air Pollution and Climatic Changes on the Rising Trends in Respiratory Allergy显示文摘 | D AMATO G LICCARDI G D AMATO M | 2001 | Respir Med2001，95，： | 1 |
| 13 | Update on the biology and therapy of gastrointestinal stromal tumors显示文摘 | D'Amato G Steinert D M McAuliffe J C | 2005 | Cancer Control2005，12，1： | 1 |
| 14 | Detection of parietaria judaica airborne allergenic activity:comparison between immunochemical and morphological methods including clinical evaluation显示文摘 | D′Amato G Gentili M Russo M | | 0，，： | 1 |
| 15 | Update on the biology and therapy of gastnintestinal stromal tumo 显示文摘 | D Amato G Steinert DM M eAuliffe JC | 2005 | Cane- er Control2005，12，1： | 1 |
| 16 | Effect of boat noise on the behaviour of bluefin tuna Thunnus thynnus in the Mediterranean Sea显示文摘 | Sara G Dean J M D'Amato D | 2007 | Marine Ecology Progress Series2007，331，： | 1 |
| 17 | Role of calcium in E-selectin induced phenotype of T84 colon carcinoma cells显示文摘 | D' Amato M Flugy AM Alaimo G | 2003 | Biochem Biophys Res Commun2003，301，4： | 1 |
| 18 | Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles显示文摘 | Amato G Conte M Mazziotti G | 2003 | Obstet Gynecol2003，101，6： | 1 |
| 19 | Pollen-related allergy in Europe显示文摘 | D'amato G Spieksma F T M Liccardi G | 1998 | Allergy1998，53，6： | 1 |
| 20 | Photodynamic therapy of circumscribed choroidal hemangioma显示文摘 | Porrini G Giovannini A Amato G loni A Pantanetti M | 2003 | Ophthalrnology2003，110，： | 1 |
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