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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 3 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 4 | Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: A tissue microarray-based study显示文摘 | Fabiano P. Saggioro Luciano Neder Jo?o Norberto Stávale Aline Nazareth P. Paix?o-Becker Suzana M.F. Malheiros Fernando A. Soares José Eymard H. Pittella Caio César M.S. Matias Benedicto O. Colli Carlos Gilberto Carlotti Marcello Franco | 2013 | Pathology - Research and Practice2013，，： | 1 |
| 5 | Resveratrol preconditioning modulates inflammatory response in the rat hippocampus following global cerebral ischemia显示文摘 | Fabrício Sim?o Aline Matté Aline S. Pagnussat Carlos Alexandre Netto Christianne G. Salbego | 2012 | Neurochemistry International2012，，5： | 1 |
| 6 | The effete of auc and cmax of esomeprazole on acid secretion and intragastric PH显示文摘 | Junghard o hassan Alin M hasselgren G | 2000 | Gastroenterology2000，118，： | 1 |
| 7 | Lymphangioma of the esophagus treated with endoscopic submucosal resection 显示文摘 | Sushil A Aline PC Metin O | 2007 | J Gastroenterol Hepatol2007，22，2： | 1 |
| 8 | Antioxidant activities of flavonol derivatives from the leaves and stem bark of Scutia buxifolia Reiss显示文摘 | Aline Augusti Boligon Romaiana Picada Pereira Andriéli Cassel Feltrin Michel Mansur Machado Vanessa Janovik Jo?o Batista Teixeira Rocha Margareth Linde Athayde | 2009 | Bioresource Technology2009，，24： | 1 |
| 9 | The effect of cadmium on antioxidant responses and the susceptibility to oxidative stress in the hydrothermal vent mussel Bathymodiolus azoricus显示文摘 | Rui Company Angela Serafim Richard Cosson Lionel Camus Bruce Shillito Aline Fiala-Médioni Maria Jo?o Bebianno | 2006 | Marine Biology2006，，4： | 1 |
| 10 | Mechanical or bioprosthetic valves in the elderly:a 20-Year comparison显示文摘 | Sidhu P Kane O Alin H | 2001 | Ann J Thorac Surg2001，71，5： | 1 |
| 11 | Climate change decreases aquatic ecosystem productivity of Lake Tanganyika, Africa显示文摘 | O'REILLY C M ALIN S R PLISNIER P D | 2003 | Nature2003，424，6950： | 1 |
| 12 | Corrosion morphologies on magnesium alloy AZ91 显示文摘 | LUNDER O LEIN J E HESJEVIK S M ALINE T K NISANCIOGLU K | 1994 | Materials and Corrosion1994，45，6： | 1 |
| 13 | Evaluation of Hepatobiliary Excretion and Enterobiliary Reflux in Rats with Biliary Obstruction Submitted to Bilioduodenal or Biliojejunal Anastomosis显示文摘 | Robson Azevedo Dutra José Sebasti?o Santos Whemberton Martins Araújo Marcus Vinicius Sim?es Aline Nazareth Paiva Paix?o-Becker Luciano Neder | 2008 | Digestive Diseases and Sciences2008，，4： | 1 |
| 14 | Climate changedecreases aquatic ecosystem productivity of Lake Tanganyika,Africa显示文摘 | O'Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，6950： | 1 |
| 15 | Climate change decreases aquatic ecosystem productivity of Lake Tanganyi- ka, Africa 显示文摘 | O' Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，： | 1 |
| 16 | Release of Trace Elements in Wetlands: Role of Seasonal Variability显示文摘 | GWENAELLE O L GERARD G ALINE D et 02 | 2001 | Water Research2001，35，4： | 1 |
| 17 | Climate change de- creases aquatic ecosystem productivity of Lake Tanganyika, Afri- ca显示文摘 | O'Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，6950： | 1 |
| 18 | Glucose varlability and mortality in patients with sepsis显示文摘 | Alin A O'brien JM jr dungan K | | 0，，11： | 1 |
| 19 | Eco-friendly synthesis of imines by ultrasound irradiation显示文摘 | Karla P. Guzen Alexandre S. Guarezemini Aline T.G. órf?o Rodrigo Cella Claudio M.P. Pereira Hélio A. Stefani | 2007 | Tetrahedron Letters2007，，10： | 1 |
| 20 | Climate change decreases aquatic ecosystem productivity of Lake Tanganyika, Africa显示文摘 | O'Reilly C M Alin S R Plisnier P D | 2003 | Nature2003，424，6950： | 1 |
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