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| 1 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 2 | Depression and quality of life in cancer patients with and without pain:The role of pain beliefs显示文摘 | Azadeh T Ali M Rasool R | 2008 | BMC Cancer2008，8，： | 1 |
| 3 | Gill net selectivity in Lake Nubia fisheries 显示文摘 | Ali M T Abu-Gideiril Y B | 1984 | Hydrobiologia1984，110，： | 1 |
| 4 | Natural convection radiation interaction in boundary layer flow over horizontal surface显示文摘 | Ali M M Chen T S Armaly B | 1984 | A/AA J1984，22，： | 1 |
| 5 | Immunoscreening of a cDNA library from a lung cancer cell line using autologous patient serum:identification of XAGE-1b as a dominant antigen and its immunogenicity in lung adenocarcinoma显示文摘 | Ali Eldib AM Ono T Shimono M | 2004 | Int J Cancer2004，108，： | 1 |
| 6 | Gastroparesis显示文摘 | Ali T Hasan M Hamadani M | | 0，，03： | 1 |
| 7 | Sulfur-containing amino acid metabolism in parasitic protozoa显示文摘 | NOZAKI T ALI V TOKORO M | 2005 | Adv Parasitol2005，60，： | 1 |
| 8 | Electrodeposition of aluminum- chromium alloys from AIC13 -BPC melt and its corrosion and high temperature oxidation behaviors显示文摘 | Ali M R Nishikata A Tsuru T | 1997 | Electrochimica Acta1997，42，15： | 1 |
| 9 | MHD flows of a second grade fluid between two side walls perpendicular to a plate through a porous medium 显示文摘 | Khan M Ali S H Hayat T | 2008 | Int J Nonlinear Mech2008，43，4： | 1 |
| 10 | The occurrence of Potato virus Y on potato in Syria显示文摘 | Chikh Ali M Katayama K Maoka T | 2006 | Jpn J Trop Agric2006，50，： | 1 |
| 11 | Rapid genomic DNA extraction (RGDE) 显示文摘 | Ali S M Mahnaz S Mahmood T | 2008 | Forensic Science International: Genetics Supplement Series2008，1，1： | 1 |
| 12 | 显示文摘 | Milovzorov D E Ali A M Inokuma T | 2001 | Thin Solid Films2001，382，： | 1 |
| 13 | Anaerobic treatment of agricultural residue based pulp and paper mill effluents for AOX and COD reduction显示文摘 | Ali M Sreekrishnan T R | 2000 | Process Biochemistry2000，36，12： | 1 |
| 14 | Moving beyond the fourth dimension with an IFC-based single project database 显示文摘 | Ali M T Ghassan A | 2005 | Automation in Cxmstruction2005，14，1： | 1 |
| 15 | Investigation of the aerodynamic characteristics of an aerofoil shaped fuselage UAV model显示文摘 | ALAM J MAMUN M ALI T A | 2014 | Procedia Engineering2014，90，： | 1 |
| 16 | Anxiety and depression in patients with gastrointestinal cancer:Does knowledge of cancer diagnosis matter-显示文摘 | Azadeh T Mohammad A Ali M | 2007 | BMC Gastroenterology2007，7，： | 1 |
| 17 | Development of heavy oil hydrocracking catalysts using amorphous silica-alumina and zeolites as catalyst supports显示文摘 | Ali M A Tatsumi T Masuda T | 2002 | Appl Catal A: Gen2002，233，： | 1 |
| 18 | Low cost adsorbents for the removal of organic pollutants from wastewater显示文摘 | Ali I Asim M Khan T A | 2012 | J Environ Manage2012，113，1： | 1 |
| 19 | Purificationand characterizationof milk clotting enzyme produced by Bacillussphaericus显示文摘 | EL-BENDARY M A MOHARAM M E ALI T H | 2007 | J Appl Sci Res2007，3，8： | 1 |
| 20 | Persistent organochlorine pesticides (OCPs) in fiver waters of Southern part of Okinawa Island, Japan显示文摘 | Imo T S Hirosawa E Ali S M | 2006 | Geochimica et Cosmochimica Acta2006，70，18： | 1 |
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