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| 1 | Surgical strategy for bile duct cancer:Advances and current limitations显示文摘The aim of this review is to describe recent advances and topics in the surgical management of bile duct cancer.Radical resection with a microscopically negative margin(R0)is the only way to cure cholangiocarcinoma and is associated with marked survival advantages compared to margin-positive resections.Complete resection of the tumor is the surgeon’s ultimate aim,and several advances in the surgical treatment for bile duct cancer have been made within the last two decades.Multidetector row computed tomography has emerged as an indispensable diagnostic modality for the precise preoperative evaluation of bile duct cancer,in terms of both longitudinal and vertical tumor invasion.Many meticulous operative procedures have been established,especially extended hepatectomy for hilar cholangiocarcinoma,to achieve a negative resection margin,which is the only prognostic factor under the control of the surgeon.A complete caudate lobectomy and resection of the inferior part of Couinaud’s segmentⅣcoupled with right or left hemihepatectomy has become the standard surgical procedure for hilar cholangiocarcinoma,and pyloruspreserving pancreaticoduodenectomy is the first choice for distal bile duct cancer.Limited resection for middle bile duct cancer is indicated for only strictly selected cases.Preoperative treatments including biliary drainage and portal vein embolization are also indicated for only selected patients,especially jaundiced patients anticipating major hepatectomy.Liver transplantation seems ideal for complete resection of bile duct cancer,but the high recurrence rate and decreased patient survival after liver transplant preclude it from being considered standard treatment.Adjuvant chemotherapy and radiotherapy have a potentially crucial role in prolonging survival and controlling local recurrence,but no definite regimen has been established to date.Further evidence is needed to fully define the role of liver transplantation and adjuvant chemo-radiotherapy. | Nobuhisa Akamatsu Yasuhiko Sugawara Daijo Hashimoto | 2011 | World Journal of Clinical Oncology2011，2，2： | 27 |
| 2 | Living-donor vs deceased-donor liver transplantation for patients with hepatocellular carcinoma显示文摘With the increasing prevalence of living-donor liver transplantation(LDLT) for patients with hepatocellular carcinoma(HCC),some authors have reported a potential increase in the HCC recurrence rates among LDLT recipients compared to deceased-donor liver transplantation(DDLT) recipients.The aim of this review is to encompass current opinions and clinical reports regarding differences in the outcome,especially the recurrence of HCC,between LDLT and DDLT.While some studies report impaired recurrence- free survival and increased recurrence rates among LDLT recipients,others,including large database studies,report comparable recurrence- free survival and recurrence rates between LDLT and DDLT.Studies supporting the increased recurrence in LDLT have linked graft regeneration to tumor progression,but we found no association between graft regeneration/initial graft volume and tumor recurrence among our 125 consecutive LDLTs for HCC cases.In the absence of a prospective study regarding the use of LDLT vs DDLT for HCC patients,there is no evidence to support the higher HCC recurrence after LDLT than DDLT,and LDLT remains a reasonable treatment option for HCC patients with cirrhosis. | Nobuhisa Akamatsu Yasuhiko Sugawara Norihiro Kokudo | 2014 | World Journal of Hepatology2014，6，9： | 13 |
| 3 | Frequent and prolonged nocturnal occupation of port areas by Yangtze finless porpoises (Neophocaena asiaeorientalis): Forced choice for feeding?显示文摘During the Yangtze Freshwater Dolphin Expedition 2012,Yangtze finless porpoises(Neophocaena asiaeorientalis)were acoustically monitored in 9 port areas at night.During 6566 min of nocturnal monitoring,porpoise sonar was detected for 488 min(7.43%of the total time).Of all 81 encounters,the longest echolocation span obtained was 102.9 min,suggesting frequent and prolonged porpoise occupation of the port areas.A combined total of 2091 click trains were recorded,with 129(6.2%)containing minimum inter-click intervals(ICIs)below 10 ms(termed a buzz).Buzzes with a decrease in ICIs and search and approach phases that resembled feeding echolocation signals accounted for 44.2%(N=52)of all buzzes.Buzzes with an increase in ICIs,suggesting a mirrored prey capture phase,accounted for 20.2%(N=26)and could reflect attempts to locate escaped prey because they were followed by approach-phase feeding buzzes.Anecdotal evidence of porpoises fleeing the proximity of vessels was observed.The recordings indicating clusters of porpoises feeding near the port areas suggest a forced choice for feeding due to the relatively higher prey availability in the port areas compared to other areas in the Yangtze River that are probably overfished. | Zhitao WANG Tomonari AKAMATSU Zhigang MEI Lijun DONG Tomohito IMAIZUMI Kexiong WANG Ding WANG | 2015 | Integrative Zoology2015，10，1： | 6 |
| 4 | Pulmonary embolism after arterial chemoembolization for hepatocellular carcinoma: An autopsy case report显示文摘We report an extremely rare case of pulmonary lipiodol embolism with acute respiratory distress syndrome(ARDS) after transcatheter arterial chemoembolization(TACE) for hepatocellular carcinoma(HCC). A 77-yearold man who was diagnosed with a huge HCC wasadmitted for TACE. Immediately after the procedure, this patient experienced severe dyspnea. We suspected that his symptoms were associated with a pulmonary lipiodol embolism after TACE, and we began intensive treatment. However, his condition did not improve, and he died on the following day. A subsequent autopsy revealed that the cause of death was ARDS due to pulmonary lipiodol embolism. No cases have been previously reported for which an autopsy was performed to explain the most probable mechanism of pulmonary lipiodol embolism; thus, ours is the first report for such a rare case. | Keiichi Hatamaru Shunjiro Azuma Takuji Akamatsu Takeshi Seta Shunji Urai Yoshito Uenoyama Yukitaka Yamashita Kazuo Ono | 2015 | World Journal of Gastroenterology2015，21，4： | 5 |
| 5 | Helicobacter heilmannii sensu stricto-related gastric ulcers:A case report显示文摘A spiral bacterium(SH9),morphologically different from Helicobacter pylori(H.pylori),was found in a 62-yearold woman’s gastric mucosa.Gastroscopic examination revealed multiple gastric ulcers near the pyloric ring;mapping gastric biopsy showed mild mononuclear infiltration with large lymphoid follicles in the antrum,without corpus atrophy.Urea breath test and H.pylori culture were negative,but Giemsa staining of biopsies revealed tightly coiled bacteria that immunostained with anti-H.pylori antibody.Sequencing of SH9 16S rRNA and the partial urease A and B subunit genes showed that the former sequence had highest similarity(99%;1302/1315 bp)to Helicobacter heilmannii(H.heilmannii)sensu stricto(H.heilmannii s.s.)BC1 obtained from a bobcat,while the latter sequence confirmed highest similarity(98.3%;1467/1493 bp)to H.heilmannii s.s.HU2 obtained from a human.The patient was diagnosed with multiple gastric ulcers associated with H.heilmannii s.s.infection.After triple therapy(amoxicillin,clarithromycin,and lansoprazole)with regimen for eradicating H.pylori,gastroscopy showed ulcer improvement and no H.heilmannii s.s.upon biopsy. | Takehisa Matsumoto Masatomo Kawakubo Taiji Akamatsu Naohiko Koide Naoko Ogiwara Seiko Kubota Mitsutoshi Sugano Yoshiyuki Kawakami Tsutomu Katsuyama Hiroyoshi Ota | 2014 | World Journal of Gastroenterology2014，20，12： | 4 |
| 6 | Late-onset acute rejection after living donor liver transplantation显示文摘AIM: To investigate the incidence and risk factors of late-onset acute rejection (LAR) and to clarify the effectiveness of our immunosuppressive regime consisting of life-long administration of tacrolimus and steroids. METHODS: Adult living donor liver transplantation recipients (n = 204) who survived more than 6 mo after living donor liver transplantation were enrolled. Immunosuppression was achieved using tacrolimus and methylprednisolone. When adverse effects of tacrolimus were detected, the patient was switched to cyclosporine. Six months after transplantation, tacrolimus or cyclosporine was carefully maintained at a therapeutic level. The methylprednisolone dosage was maintained at 0.05 mg/kg per day by oral administration. Acute rejections that occurred more than 6 mo after the operation were defined as late-onset. The median follow- up period was 34 mo. RESULTS: LAR was observed in 15 cases (7%) and no chronic rejection was observed. The incidence of hyperlipidemia, chronic renal failure, new-onset post- transplantation diabetes, and deep fungal infection were 13%, 2%, 24%, and 17%, respectively. Conversion from tacrolimus to cyclosporine was required in 38 patients (19%). Multivariate analysis revealed that a cyclosporine- based regimen was significantly associated with LAR. CONCLUSION: Both LAR and drug-induced adverseevents happen at a low incidence, supporting the safety and efficacy of the present immunosuppression regimen for living donor liver transplantation. | Nobuhisa Akamatsu Yasuhiko Sugawara Sumihito Tamura Junichi Keneko Yuichi Matsui Kiyoshi Hasegawa Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，41： | 4 |
| 7 | Efficacy of mycofenolate mofetil for steroid-resistant acute rejection after living donor liver transplantation显示文摘瞄准:在类固醇作为抑制免疫力的药讨论 mycophenolate mofetil (MMF ) 的使用在肝移植以后的抵抗拒绝。方法:经历了生活施主肝移植(LDLT ) 的 260 个成年病人的临床的记录被考察。Tacrolimus 和甲基氢化尼松被用于主要免疫力的抑制。尖锐拒绝首先与类固醇被对待。当类固醇抵抗发生了时,病人与类固醇和 MMF 的联合被对待。Anti-T-cell 单音的同种细胞的抗体予不对在有 MMF 的联合的类固醇应答的病人被以。结果:90 的一个总数(35%) 病人们开发了尖锐拒绝。第一个事件的从移植的中部的间隔时间是 15 d。54 个病人是类固醇抵抗。44 个病人与 MMF 并且留下被对待 10 要求的 anti-T-cell 单音的同种细胞的抗体治疗。到长期的拒绝的前进在一个病人被观察。骨髓抑制和胃肠的症状是与 MMF 使用联系的最普通的副作用。机会主义的感染没有重要增加。结论:我们的结果证明 MMF 为在有在 LDLT 以后的尖锐拒绝的病人的营救治疗是一个有势力和安全抑制免疫力的代理人。 | Nobuhisa Akamatsu Yasuhiko Sugawara Sumihito Tamura Yuichi Matsui Junichi Kaneko Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，30： | 3 |
| 8 | Stable carbon, nitrogen, and oxygen isotope analysis as a potential tool for verifying geographical origin of beef显示文摘 | Rumiko Nakashita Yaeko Suzuki Fumikazu Akamatsu Yoshiko Iizumi Takashi Korenaga Yoshito Chikaraishi | 2008 | Analytica Chimica Acta2008，，1： | 2 |
| 9 | New approaches in laparoscopic surgery for colorectal diseases: The totally laparoscopic and single-incision approaches显示文摘More than 20 years have passed since the first report of laparoscopic colectomy in 1991. Thereafter, laparoscopic surgery for the management of colorectal diseases has been widely accepted as a prevailing option because of improved cosmetic outcomes, less postoperative pain, and shorter hospital stay in comparison with open surgery. To further the principle of minimally invasive surgery, two new approaches have been developed in this rapidly evolving field. The first is the totally laparoscopic approach. Currently most of standard techniques inevitably involve an abdominalincision for retrieval of the specimen and preparation for anastomosis, which might compromise the benefits of laparoscopic surgery. The totally laparoscopic approach dispenses with this incision by combining completely intraperitoneal anastomosis with retrieval of the specimen via a natural orifice, such as the anus or the vagina. Our new and reliable technique for intraperitoneal anastomosis is also described in detail in this article. The second is the single-incision approach. While three to six ports are needed in standard laparoscopic surgery, the single-incision approach uses the umbilicus as the sole access to the abdominal cavity. All of the laparoscopic procedures are performed entirely through the umbilicus, in which the surgical scar eventually becomes hidden, achieving virtually scarless surgery. This article reviews the current status of these two approaches and discusses the future of minimally invasive surgery for colorectal diseases. | Hiroki Akamatsu Masahiro Tanemura Kentaro Kishi Mitsuyoshi Tei Toru Masuzawa Masaki Wakasugi | 2015 | World Journal of Surgical Procedures2015，5，1： | 2 |
| 10 | A simple and safe technique for esophagojejunostomy using the hemidouble stapling technique in laparoscopy-assisted total gastrectomy显示文摘 | Takeshi Omori Tsukasa Oyama Shin Mizutani Masayuki Tori Kiyokazu Nakajima Hiroki Akamatsu Masaaki Nakahara Toshirou Nishida | 2009 | The American Journal of Surgery2009，，1： | 2 |
| 11 | Liver Transplantation and Hepatitis C显示文摘 | Nobuhisa Akamatsu Yasuhiko Sugawara Mario Reis Alvares-da-Silva | 2012 | International Journal of Hepatology2012，，： | 2 |
| 12 | Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction显示文摘Pancreatic ductal adenocarcinoma(PDAC) has the poorest prognosis of all malignancies and is largely resistant to standard therapy. Novel treatments against PDAC are desperately needed. Anti-Gal is the most abundant natural antibody in humans,comprising about 1% of immunoglobulins and is also naturally produced in apes and Old World monkeys. The anti-Gal ligand is a carbohydrate antigen called 'α-gal epitopes' with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as major carbohydrate antigens in non-primate mammals,prosimians,and New World monkeys. Anti-Gal is exploited in cancer vaccines to increase the immunogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tumor lysates are processed to express α-gal epitopes. Vaccination with these components results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine components,transport of the vaccine tumor membranes to draining lymph nodes,and processing and presentation of tumor-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against multiple TAAs contained in PDAC cells and induce activation of multiple tumor-specific T cells. Here,we review new areas of clinical importance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in immunotherapy against PDAC. | Masahiro Tanemura Eiji Miyoshi Hiroaki Nagano Hidetoshi Eguchi Katsuyoshi Matsunami Kiyomi Taniyama Nobutaka Hatanaka Hiroki Akamatsu Masaki Mori Yuichiro Doki | 2015 | World Journal of Gastroenterology2015，21，40： | 2 |
| 13 | Treatment of epilepsy显示文摘 | Tsuji S Akamatsu N | 2008 | Rinsho Shinkeigaku2008，48，8： | 1 |
| 14 | Enhancementmode AlGaN/AlN/GaN high electron mobility transistor with low on-state resistance and high breakdown voltage 显示文摘 | Ohmaki Y Tanimoto M Akamatsu S | 2006 | Jpn J Appl Phys2006，45，44： | 1 |
| 15 | Endogenous ET-1 con- tributes to liver injury induced by galactosamine and endotoxin in isolated perfused rat liver 显示文摘 | OHUCHI T TADA K AKAMATSU K | 1995 | Am J Physiol1995，268，61： | 1 |
| 16 | Precipitation Behavior of Sulfides in Ti-added Ultra Low-carbon Steels in Austenite显示文摘 | Naoki YOSHINAGA Kohsaku USHIODA Satoshi AKAMATSU | 1994 | ISIJ International1994，34，1： | 1 |
| 17 | Neural stem cell as a source of graft material for transplantation in neuronal disease 显示文摘 | AKAMATSU W OKANO H | 2001 | No To Hattatsu2001，33，2： | 1 |
| 18 | Hemophagocytic syndrome after adult-to-adult living donor liver transplantation显示文摘 | Akamatsu N Sugawara Y Tamura S | 2006 | Transplant-Proc2006，38，5： | 1 |
| 19 | Automatic classification of single facial images显示文摘 | MICHAEL J L BUDYNEK J AKAMATSU S | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，12： | 1 |
| 20 | A comparison of outcomes of endoscopic submucosal dissection (ESI)) tor early gastric neoplasms between high-volume and low- volume centers: multi-center retrospective questionnaire study conducted by lhe Nagann ESD Study Group 显示文摘 | Hotta K Oyama T Akamatsu T | 2010 | Inlern Med2010，49，4： | 1 |
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