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| 1 | Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury显示文摘Neglected for years, astrocytes are now recognized to fulfill and support many, if not all, homeostatic functionsof the healthy central nervous system(CNS). During neurodegenerative diseases such as amyotrophic lateral sclerosis(ALS) and spinal cord injury(SCI), astrocytes in the vicinity of degenerating areas undergo both morphological and functional changes that might compromise their intrinsic properties. Evidence from human and animal studies show that deficient astrocyte functions or loss-of-astrocytes largely contribute to increased susceptibility to cell death for neurons, oligodendrocytes and axons during ALS and SCI disease progression. Despite exciting advances in experimental CNS repair, most of current approaches that are translated into clinical trials focus on the replacement or support of spinal neurons through stem cell transplantation, while none focus on the specific replacement of astroglial populations. Knowing the important functions carried out by astrocytes in the CNS, astrocyte replacement-based therapies might be a promising approach to alleviate overall astrocyte dysfunction, deliver neurotrophic support to degenerating spinal tissue and stimulate endogenous CNS repair abilities. Enclosed in this review, we gathered experimental evidence that argue in favor of astrocyte transplantation during ALS and SCI. Based on their intrinsic properties and according to the cell type transplanted, astrocyte precursors or stem cell-derived astrocytes promote axonal growth, support mechanisms and cells involved in myelination, are able to modulate the host immune response, deliver neurotrophic factors and provide protective molecules against oxidative or excitotoxic insults, amongst many possible benefits. Embryonic or adult stem cells can even be genetically engineered in order to deliver missing gene products and therefore maximize the chance of neuroprotection and functional recovery. However, before broad clinical translation, further preclinical data on safety, reliability and therapeutic efficiency should be collected. Although several technical challenges need to be overcome, we discuss the major hurdles that have already been met or solved by targeting the astrocyte populationin experimental ALS and SCI models and we discuss avenues for future directions based on latest molecular findings regarding astrocyte biology. | Charles Nicaise Dinko Mitrecic Aditi Falnikar Angelo C Lepore | 2015 | World Journal of Stem Cells2015，7，2： | 13 |
| 2 | 基于论文和专利分析的人工智能发展态势研究显示文摘为揭示当前人工智能领域的发展态势,本文统计分析了当前各主要国家/地区出台的顶层政策规划,并重点分析了人工智能领域论文和专利的年度变化、国家分布、主要机构、技术主题、方向对比和国际合作等。结果显示:当前人工智能科技成果产出正处于快速发展阶段,中美两国引领了人工智能领域科研成果;中国在该领域发文量接近美国,专利数量已超过美国;中国科研机构已具备开展国际竞争的能力,但市场主体的成果产出与先进国家尚有差距,国际化布局程度较低;如何提升机器的“认知能力”是当前人工智能研究的关注焦点。最后,基于分析,提出了对中国人工智能发展的启示。 | 周伯柱 Aditi GUPTA | 2019 | 世界科技研究与发展2019，41，4： | 8 |
| 3 | A Chance-Constrained Wind Range Quantification Approach to Robust SCUC by Determining Dynamic Uncertainty Intervals显示文摘With increasing penetration of wind energy,the variability and uncertainty of wind resources have become important factors for power systems operation.In particular,an effective method is required for identifying the stochastic range of wind power output,in order to better guide the operational security of power systems.This paper proposes a metric to determine accurate wind power output ranges so that the probability of actual wind power outputs being out of the range would be less than a small pre-defined value.A mixed-integer linear programming(MILP)based chance-constrained optimization model is proposed for efficiently determining optimal wind power output ranges,which are quantified via maximum and the minimum wind generation levels with respect to a certain time interval.The derived wind power range is then used to construct dynamic uncertainty intervals for the robust securityconstrained unit commitment(SCUC)model.A comparison with the deterministic SCUC model and the traditional robust SCUC model with presumed static uncertainty interval demonstrates that the proposed approach can offer more accurate wind power variabilities(i.e.,different variability degrees with respect to different wind power output levels at different time periods).The proposed approach is also shown to offer more effective and robust SCUC solutions,guaranteeing operational security and economics of power systems.Numerical case studies on a 6-bus system and the modified IEEE 118-bus system with realworld wind power data illustrate the effectiveness of the proposed approach. | Aditi Upadhyay Bingqian Hu Jie Li Lei Wu | 2016 | CSEE Journal of Power and Energy Systems2016，2，1： | 6 |
| 4 | Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces显示文摘All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come. | Tarun Bhatt Aditi Sharma Sanjeev Puri Anu Priya Minhas | 2020 | Rice science2020，27，5： | 6 |
| 5 | Low-cost high entropy alloy(HEA)for high-efficiency oxygen evolution reaction(OER)显示文摘Oxygen evolution reaction(OER)is the key step involved both in water splitting devices and rechargeable metal-air batteries,and hence,there is an urgent need for a stable and low-cost material for efficient OER.In the present investigation,Co-Fe-Ga-NiZn(CFGNZ)high entropy alloy(HEA)has been utilized as a low-cost electrocatalyst for OER.Herein,after cyclic voltammetry activation,CFGNZ-nanoparticles(NPs)are covered with oxidized surface and form high entropy(oxy)hydroxides(HEOs),exhibiting a low overpotential of 370 mV to achieve a current density of 10 mA/cm^(2)with a small Tafel slope of 71 mV/dec.CFGNZ alloy has higher electrochemical stability in comparison to state-of-the art RuO2 electrocatalyst as no degradation has been observed up to 10 h of chronoamperometry.Transmission electron microscopy(TEM)studies after 10 h of long-term chronoamperometry test showed no change in the crystal structure,which confirmed the high stability of CFGNZ.The density functional theory(DFT)based calculations show that the closeness of d(p)-band centers to the Fermi level(EF)plays a major role in determining active sites.This work highlights the tremendous potential of CFGNZ HEA for OER,which is the primary reaction involved in water splitting. | Lalita Sharma Nirmal Kumar Katiyar Arko Parui Rakesh Das Ritesh Kumar Chandra Sekhar Tiwary Abhisek K.Singh Aditi Halder Krishanu Biswas | 2022 | Nano Research2022，15，6： | 5 |
| 6 | High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX显示文摘 | Indrabahadur Singh Nihan Ozturk Julio Cordero Aditi Mehta Diya Hasan Claudia Cosentino Carlos Sebastian Marcus Kruger Mario Looso Gianni Carraro Saverio Bellusci Werner Seeger Thomas Braun Raul Mostoslavsky Guillermo Barreto | 2015 | Cell Research2015，25，7： | 5 |
| 7 | Advances in orthodontic clear aligner materials显示文摘Rapid technological improvements in biomaterials,computer-aided design(CAD)and manufacturing(CAM)have endorsed clear aligner therapy(CAT)as a mainstay of orthodontic treatment,and the materials employed for aligner fabrication play an all-important role in determining the clinical performance of clear aligners.This narrative review has attempted to comprehensively encompass the entire gamut of materials currently used for the fabrication of clear aligners and elucidate their characteristics that are crucial in determining their performance in an oral environment.Historical developments and current protocols in aligner fabrication,features of contemporary bioactive materials,and emerging trends related to CAT are discussed.Advances in aligner material chemistry and engineering possess the potential to bring about radical transformations in the therapeutic applications of CAT;in the absence of which,clear aligners would continue to underperform clinically,due to their inherent biomechanical constraints.Finally,while innovations in aligner materials such as shape memory polymers,direct three-dimensional(3D)printed clear aligners and bioactive materials combined with clear aligner materials are essential to further advance the applications of CAT;increased awareness of environmental responsibilities among aligner manufacturers,aligner prescribing clinicians and aligner users is essential for better alignment of our climate change goals towards a sustainable planet. | Yashodhan M.Bichu Abdulraheem Alwafi Xiaomo Liu James Andrews Bjorn Ludwig Aditi Y.Bichu Bingshuang Zou | 2023 | Bioactive Materials2023，，4： | 4 |
| 8 | Deconstructing brain-derived neurotrophic factor actions in adult brain circuits to bridge an existing informational gap in neuro-cell biology显示文摘Brain-derived neurotrophic factor(BDNF) plays an important role in neurodevelopment,synaptic plasticity,learning and memory,and in preventing neurodegeneration.Despite decades of investigations into downstream signaling cascades and changes in cellular processes,the mechanisms of how BDNF reshapes circuits in vivo remain unclear.This informational gap partly arises from the fact that the bulk of studies into the molecular actions of BDNF have been performed in dissociated neuronal cultures,while the majority of studies on synaptic plasticity,learning and memory were performed in acute brain slices or in vivo.A recent study by Bowling-Bhattacharya et al.,measured the proteomic changes in acute adult hippocampal slices following treatment and reported changes in proteins of neuronal and non-neuronal origin that may in concert modulate synaptic release and secretion in the slice.In this paper,we place these findings into the context of existing literature and discuss how they impact our understanding of how BDNF can reshape the brain. | Heather Bowling Aditi Bhattacharya Eric Klann Moses V.Chao | 2016 | Neural Regeneration Research2016，11，3： | 4 |
| 9 | Skeletal myogenesis by human embryonic stem cells显示文摘我们检验了在一个 xeno 移植动物的细胞建模的人的胚胎的茎(hES ) 的 myogenic 潜力。这里,我们证明区分开来与 hES 房间的先锋能在成年环境经历 myogenesis 并且在 myogenic 系产生房间类型的一个范围。这研究提供 hES 房间能在 vivo 改革肌肉和卫星房间并且是为对待肌肉的另一种有希望的房间类型的直接证据除了另外的 myogenic 房间类型的退化混乱。房间研究(2006 ) 16:713-722。做 i:10.1038/sj .cr.7310080;出版联机 2006 年 6 月 20 日。 | Jun Ke Zheng Yi Wang Aditi Karandikar Qian Wang Hui Gai Ai Lian Liu Chao Peng Hui Zhen Sheng | 2006 | Cell Research2006，16，8： | 4 |
| 10 | Alzheimer's disease: the silver tsunami of the 21^(st) century显示文摘Alzheimer's disease(AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42(Aβ42) plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to(i) study etiology of disease,(ii) look for genetic modifiers, and(iii) identify chemical inhibitors that can block neurodegeneration and help to find cure for this disease. An insect model of Drosophila melanogaster has also provided new insights into the disease. Here we will discuss the utility of the Drosophila eye model to study Alzheimer's disease. | Ankita Sarkar Madison Irwin Aditi Singh Matthew Riccetti Amit Singh | 2016 | Neural Regeneration Research2016，11，5： | 4 |
| 11 | Artificial Seed Production of Tylophora indica for Interim Storing and Swapping of Germplasm显示文摘Our research work demonstrates the single bead alginate-encapsulation, interim storing and conversion of Tylophora indica(Burm. Fil.) Merrill.Most effective encapsulation of in vitro nodal segments [(4 ± 1) mm long], ensuing in sphere-shaped artificial seeds of similar morphology, was achieved through 75 mmol·L^(-1)calcium chloride(CaCl_2 · 2H_2O) plus 3%(w/v) Na-alginate with 93.3% conversion frequency. The earliest conversion(within 7 days of incubation) of artificial seeds occurred in half-strength liquid Murashige and Skoog medium. Among the three different temperature regimes [(5 ± 1) °C,(15 ± 1) °C, and(25 ± 1) °C], storage of artificial seeds at(15 ± 1) °C executed the highest frequency of conversion(90%) after 15 days of storage. Lengthier storage significantly reduced the conversion frequency of artificial seeds irrespective of storage temperature. Nevertheless, the conversion frequency after 30 days of storage at(15 ± 1) °C was recorded at 70% without further decline even following45 days of storage, which evidently suggests that lower temperature(15 ± 1) °C is apt for storage and subsequent conversion of T. indica artificial seeds. The present protocol could be expedient for short-term storing and swapping of T. indica germplasms between national and international laboratories. | Saikat Gantait Joshitha Vijayan Adity Majee | 2017 | Horticultural Plant Journal2017，3，1： | 3 |
| 12 | Multi-criteria land evaluation for suitability analysis of wheat:a case study of a watershed in eastern plateau region,India显示文摘Improper land use results in land degradation as well as decline in agricultural productivity.To obtain optimum benefit from the land,proper utilization of its resources is necessary.Land suitability analysis is the evaluation and grouping of specific areas of land in terms of their suitability for a defined use,which is a precondition for sustainable land use planning.This study investigated the applicability of Geographical Information System(GIS)techniques in combination with multi-criteria land evaluation for analysing land suitability.The study used the weighted overlay technique for multi-criteria evaluation with GIS for the assessment of suitability of wheat cultivation in Beko watershed(Purulia,India).The watershed area is moderately suitable for wheat crop production,with constraints like imperfect drainage and poor soil depth. | Aditi SARKAR Amit GHOSH Pabitra BANIK | 2014 | Geo-Spatial Information Science2014，17，2： | 3 |
| 13 | Structure and stacking faults in layered Mg–Zn–Y alloys: A first-principles study显示文摘 | Aditi Datta U.V. Waghmare U. Ramamurty | 2008 | Acta Materialia2008，，11： | 2 |
| 14 | Meta-analysis of new genome-wide association studies of colorectal cancer risk显示文摘 | Ulrike Peters Carolyn M. Hutter Li Hsu Fredrick R. Schumacher David V. Conti Christopher S. Carlson Christopher K. Edlund Robert W. Haile Steven Gallinger Brent W. Zanke Mathieu Lemire Jagadish Rangrej Raakhee Vijayaraghavan Andrew T. Chan Aditi Hazra Dav | 2012 | Human Genetics2012，，2： | 2 |
| 15 | 地下水市场的参与:谁是卖水者?(英文)显示文摘尽管中国农村的地下水市场在最近10多年来得到了快速发展,然而相关的研究文献却凤毛麟角。通过使用来自于中国北方两省150个农户的微观调查数据,论文描述了中国农村地下水市场参与者的主要特征,并分析了影响农户卖水行为的主要因素。研究发现:那些相对富裕的、在农业活动中具有比较优势的、在本地拥有较高社会地位的农户更有可能成为地下水市场中的卖方,而交易成本的大小也会影响到农户对于地下水市场的参与。 | 米建伟 黄季焜 王金霞 Aditi Mukherji | 2008 | 自然资源学报2008，23，6： | 2 |
| 16 | Experience with hemoadsorption (CytoSorb~?) in the management of septic shock patients显示文摘BACKGROUND Cytokines and inflammatory mediators are the hallmarks of sepsis.Extracorporeal cytokine hemoadsorption devices are the newer clinical support system to overcome the cytokine storm during sepsis.AIM To retrospectively evaluate the clinical outcomes of patients admitted in intensive care unit with septic shock with different etiologies.METHODS The laboratory parameters including biomarkers such as procalcitonin,serum lactate and C-reactive protein;and the hemodynamic parameters;mean arterial pressure,vasopressor doses,sepsis scores,cytokine levels and other vital parameters were evaluated.We evaluated these outcomes among survivors and non-survivors.RESULTS Of 100 patients evaluated,40 patients survived.Post treatment,the vasopressors dosage remarkably decreased though it was not statistically different;34.15%(P=0.0816)for epinephrine,20.5%for norepinephrine(P=0.3099)and 51%(P=0.0678)for vasopressin.In the survivor group,a remarkable reduction of biomarkers levels;procalcitonin(65%,P=0.5859),C-reactive protein(27%,P=0.659),serum lactate(27%,P=0.0159)and bilirubin(43.11%;P=0.0565)were observed from baseline after CytoSorb^® therapy.A significant reduction in inflammatory markers;interleukin 6 and interleukin 10;(87%and 92%,P<0.0001)and in tumour necrosis factor(24%,P=0.0003)was also seen.Overall,28(28%)patients who were given CytoSorb^® therapy less than 48 h after onset of septic shock survived and the maximum duration of stay for 70%of these patients in intensive care unit was less than 15 d.CONCLUSION CytoSorb^® is a safe and well tolerated rescue therapy option in patients with septic shock.However,early(preferably within<48 h after onset of septic shock)initiation could result in better clinical outcomes.Further randomized trials are needed to define the potential benefits of this new treatment modality. | Yatin Mehta Chitra Mehta Ashish Kumar Joby Varghese George Aditi Gupta Saurabh Nanda Gourav Kochhar Arun Raizada | 2020 | World Journal of Critical Care Medicine2020，9，1： | 2 |
| 17 | Nephrotic Syndrome显示文摘 | Aditi Sinha Arvind Bagga | 2012 | The Indian Journal of Pediatrics2012，，8： | 2 |
| 18 | Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients显示文摘 | Daniel Bloomfield Gary L. Carlson Aditi Sapre Diane Tribble James M. McKenney Thomas W. Littlejohn Christine McCrary Sisk Yale Mitchel Richard C. Pasternak | 2009 | American Heart Journal2009，，2： | 1 |
| 19 | Association Between Colorectal Cancer Susceptibility Loci and Survival Time After Diagnosis With Colorectal Cancer显示文摘 | Amanda I. Phipps Polly A. Newcomb Xabier Garcia–Albeniz Carolyn M. Hutter Emily White Charles S. Fuchs Aditi Hazra Shuji Ogino Hongmei Nan Jing Ma Peter T. Campbell Jane C. Figueiredo Ulrike Peters Andrew T. Chan | 2012 | Gastroenterology2012，，1： | 1 |
| 20 | Vitamin C,gastritis,and gastric disease:a historical review and update显示文摘 | Aditi A Graham DY | 2012 | Dig Dis Sci2012，57，10： | 1 |
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