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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 3 | Changes in the epidemiolngic profile of sudden infant death syndrome as rates decline among California infants:1990-1995显示文摘 | Adams E J Chavez G F Steen D | 1998 | Pediatrics1998，102，6： | 1 |
| 4 | A Light Interception Method for Measuring Row Crop Ground Cover显示文摘 | Adams J E A G F | 1977 | Soil Science Society of America Journal1977，41，4： | 1 |
| 5 | Preemptive analgesia with Ketamine显示文摘 | Miguel R Fu E Adam F et at | 2000 | Anesth Analg2000，90，： | 1 |
| 6 | A Light Interception Method for Measuring Row Crop Ground Cover显示文摘 | Adams J E A G F | 1977 | Soil Science Society of America Journal1977，41，4： | 1 |
| 7 | A Light Interception Method for measuring Row Crop Ground Cover显示文摘 | Adam J E Arkin G F | 1977 | Soil Science Society of America Jour- nal1977，41，4： | 1 |
| 8 | Ferrite devices and materials显示文摘 | Douglas Adam J Lionel E Davis Gerald F Dionne | 2002 | IEEE Transactions on Microwave Theory and Techniques2002，50，3： | 1 |
| 9 | Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke显示文摘 | Max W Adam E F Birgitta V | 2006 | Stroke2006，37，3： | 1 |
| 10 | Design of practical color filter array interpolation algorithms for digital cameras显示文摘 | Adams J E Hamilton J F | 1997 | Proc of SPIE1997，3028，： | 1 |
| 11 | Geometric morphometries: ten years of progress following the 'revolution' 显示文摘 | Adams D C Rohlf F J Slice D E | 2004 | Ital J Zool2004，71，： | 1 |
| 12 | The genome sequence of Drosophila melanogaster显示文摘 | Adams M D Celniker S E Holt R A Evans C A Gocayne J D Amanatides P G Scherer S E Li P W Hoskins R A Galle R F | | 0，，： | 1 |
| 13 | Conformal printing of electrically small antennas on three-dimensional surfaces显示文摘 | ADAMS J J DUOSS E B WALKOWSKI T F MOTALA M J AHN B Y NUZZO R G BERNHARD J T LEWIS J A | 2011 | Advanced Materials2011，23，1： | 1 |
| 14 | A Cross-Cultural Study of the Affecrive Meaning of Color显示文摘 | Adams F Osgood C E | 1973 | Journal of Cross-Cultural Psychology1973，，4： | 1 |
| 15 | A light interception method for measuring row crop ground cover显示文摘 | Adams J E Arkin G F | 1997 | Soil Science Society of America Journal1997，41，4： | 1 |
| 16 | A filed comes of age: geometric morphometrics in the 215t century 显示文摘 | Adams D C Rohlf F J Slice D E | 2013 | Hystrix2013，24，1： | 1 |
| 17 | Matrix metalloproteinase inhibitors: A review on bioanalytical methods, pharmacokinetics and metabohsm显示文摘 | Wang X Li K F Adams E | 2011 | Curr Drug Metab2011，12，4： | 1 |
| 18 | Bax crystal structures reveal how BH3domains activate Bax and nucleate its oligomerization to induce apoptosis显示文摘 | Czabotar P E Westphal D Dewson G Ma S Hockings C Fairlie W D Lee E F Yao S Robin A Y Smith B J Huang D C Kluck R M Adams J M Colman P M | 2013 | Cell2013，152，3： | 1 |
| 19 | A 20-kilodalton protein is required for efficient production of the Bacillus thuringiensis subsp,israelensis 27-kilodalton crystal protein in Escherichia coli显示文摘 | ADAMS L F JONATHAN E V WHITELY H R | 1989 | J Bacteriol1989，171，： | 1 |
| 20 | Environmental gradients,plant distribution,and species richness in arctic salt marsh near Prudhce Bay,Alaska显示文摘 | DALE W F LYNN E N ADAM H F | 2004 | Wetlands Ecology and Management2004，12，： | 1 |
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