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| 1 | Surgical treatment for liver cancer显示文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection. | Nicole C Tsim Adam E Frampton Nagy A Habib Long R Jiao | 2010 | World Journal of Gastroenterology2010，16，8： | 12 |
| 2 | 应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议显示文摘美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南,其中包括应用重组组织型纤溶酶原激活物(rt—PA)行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效,但由于患者通常在发病3h后方能到达医院,往往已经超过了用药的时间窗。因此,大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为,增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。 | del Zoppo G J Saver J L Jauch E C Adams H P Jr. | 2009 | 中国脑血管病杂志2009，6，8： | 8 |
| 3 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation显示文摘Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients. | Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 5 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 6 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 7 | Principal component analysis of dissolution data with missing elements显示文摘 | Adams E Walczak B Vervaet C Risha P G Massart D L | 1997 | Chemometrics and intelligent aboratory systems1997，，32： | 2 |
| 8 | Activation tagging identifies a gene from Petunia hybrida responsible for the production of active cytokinins in plants 显示文摘 | ZUBKO E ADAMS C J MACHAEKOVA I | 2002 | Plant J2002，29，6： | 1 |
| 9 | The sequence of the human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，： | 1 |
| 10 | Nucleotide sequence, polymorphism, and evolution of ovine MHC class Ⅱ DQA genes 显示文摘 | Scott P C Gogolin-Ewens K J Adams T E | 1991 | Immunogenetics1991，34，2： | 1 |
| 11 | Ion channels and membrane rafts in apoptosis显示文摘 | Szabò I Adams C Gulbins E | 2004 | Pflugers Arch2004，448，3： | 1 |
| 12 | The sequence of human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，5507： | 1 |
| 13 | Identification of impurities in erythromycin by liquid chromatography-mass spectrometric detection显示文摘 | Kumar Chitneni S Govaerts C Adams E | 2004 | J Chromatogr A2004，1056，1： | 1 |
| 14 | ACC/AHA2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction显示文摘 | Anderson J L Adams C D Antman E M | 2007 | Journal of the American College of Cardiology2007，50，7： | 1 |
| 15 | Plasma progesterone concentrations in pregnant and non-pregnant llamas显示文摘 | Moir C E Shiach P | 1989 | Vet Res1989，125，： | 1 |
| 16 | Recruitment Order of Motor Units in Human Vastus Lateralis Muscle Is Maintained during Fatiguing Contractions 显示文摘 | ADAM A D E LUCA C | 2003 | Neurophysiol2003，90，： | 1 |
| 17 | Mechanical devices for pelvic organ prolapse in women显示文摘 | Adams E Thomson A Maher C | 2004 | Database Syst Rev2004，17，2： | 1 |
| 18 | Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment(TOAST)显示文摘 | ADAMS H P J R DAVIS P H LEIRA E C | 1999 | Neurology1999，53，1： | 1 |
| 19 | Underwater acoustic receiver employing direct-sequence spread spectrum and spatial diversity combining for shallow-water multi-access networking显示文摘 | Tsimenidis C C Hinton O R Adams A E | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 20 | ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST- Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines( Writing Committee to Revise the 2002 Guidelines for the Manage- ment of Patients With Unstable Angina/Non - ST - Elevation Myocardi- al Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the A- merican Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine显示文摘 | Anderson J L Adams C D Amman E M | 2007 | J Am Coil Cardiol2007，50，7： | 1 |
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