|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Excretion of biliary compounds during intrauterine life显示文摘In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,respectively.However,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very poor.Although very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal liver.Therefore,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta.Owing to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine life.The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother.This may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the pregnancy.The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. | Rocio IR Macias Jose JG Marin Maria A Serrano | 2009 | World Journal of Gastroenterology2009，15，7： | 6 |
| 2 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 3 | Land cover changes and fragmentation in mountain neotropical ecosystems of Oaxaca, Mexico under community forest management显示文摘Changes in land cover have a direct impact on forest ecosystem goods and services. In this study, changes in land cover in Sierra de Juarez–Oaxaca ecosystems were estimated using a consistent processing of Landsat images and OBIA methodology. Additionally, landscape analyses using FRAGSTAT were conducted. In 2014, Sierra de Juarez–Oaxaca was covered by approximately 84% of forests, mainly pine-oak and cloud forests. After extensive deforestation until 2001, this trend was reversed and the forest cover surface area in 2014 was slightly higher than in 1979. The comparison of the landscape structure of the forested and agricultural lands suggests an increase in habitat heterogeneity. However, interspersion and juxtaposition indices, showing the patch shape by patch area and perimeter, were similar throughout the study period(1979–2014). Social and economic drivers can explain this situation: namely, community organization, forest enterprises, payment for ecosystem services programs, and changes of agricultural activity. Communities in the Sierra of Oaxaca have reforested degraded lands, created community forest enterprises, and preserved the forest under conservation schemes like those proposed by the Mexican payment for ecosystem services programs. However, their sustainable management faces internal challenges and has become highly dependent on political and institutional decisions beyond their control. | Rafael M~a Navarro Cerrillo Dennis J.Esteves Vieira Susana Ochoa-Gaona Bernardus H.J.de Jong M~a del Mar Delgado Serrano | 2019 | Journal of Forestry Research2019，30，1： | 4 |
| 4 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 5 | Perfluorocarbon in vitreoretinal surgery and preoperative bevacizumab in diabetic tractional retinal detachment显示文摘AIM: To describe the en bloc perfluorodissection(EBPD) technique and to demonstrate the applicabilityof using preoperative intravitreal bevacizumab duringsmall-gauge vitreoretinal surgery(23-gauge transconjunctival sutureless vitrectomy) in eyes with advancedproliferative diabetic retinopathy(PDR) with tractionalretinal detachment(TRD).METHODS: This is a prospective, interventional caseseries. Participants included 114(eyes) with advancedproliferative diabetic retinopathy and TRD. EBPD wasperformed in 114 eyes(consecutive patients) during23-gauge vitrectomy with the utilization of preoperativebevacizumab(1.25 mg/-0.05 mL). Patients mean age was 45 years(range, 21-85 years). Surgical time had a mean of 55 min(Range, 25-85 min). Mean follow up of this group of patients was 24 mo(range, 12-32 mo). Main outcome measures included best-corrected visual acuity(BCVA), retinal reattachment, and complications.RESULTS: Anatomic success occurred in 100%(114/-114) of eyes. Significant visual improvement [≥ 2 Early Treatment Diabetic Retinopathy Study(ETDRS) lines] was obtained in 69.2%(79/-114), in 26 eyes(22.8%) BCVA remained stable, and in 8 eyes(7%) BCVA decreased(≥ 2 ETDRS lines). Final BCVA was 20/-50 or better in 24% of eyes, between 20/-60 and 20/-400 in 46% of eyes, and worse than 20/-400 in 30% of eyes. Complications included cataract in 32(28%) eyes, iatrogenic retinal breaks in 9(7.8%) eyes, vitreous hemorrhage requiring another procedure in 7(6.1%) eyes, and phthisis bulbi in 1(0.9%) eye.CONCLUSION: This study demonstrates the usefulne-ss of using preoperative intravitreal bevacizumab and EBPD during smallgauge vitreoretinal surgery in eyes with TRD in PDR. | J Fernando Arevalo Martin A Serrano Juan D Arias | 2014 | World Journal of Diabetes2014，5，5： | 3 |
| 6 | Effects of sample pre-treatment on the δ^13C and δ^18O values of living benthic foraminifera显示文摘 | Serrano O Serrano L Mateo M A | 2008 | Chemical Geology2008，257，： | 1 |
| 7 | Detecting rich-club ordering in complex networks显示文摘 | Colizza V Flammini A Serrano M A | 2006 | Nature Physics2006，2，2： | 1 |
| 8 | Prospective clinical and manometric study of fistulotomywith primary sphincter reconstruction in the management ofrecurrent complex fistula-in-ano 显示文摘 | Pe'rez F Arroyo A Serrano P | 2006 | Int J Colorectal Dis2006，21，5： | 1 |
| 9 | Regulatory elements governing transcription in specialized myofiber subtypes 显示文摘 | Yan Z Serrano A L Schiaffino S | 2001 | The Journal of Biological Chemistry2001，276，17： | 1 |
| 10 | New strategy for the generation of specific D-peptide amyloid inhibitors 显示文摘 | Esteras-Chopo A Pastor MT Serrano L | 2008 | J Mol Biol2008，377，5： | 1 |
| 11 | In vivo antioxidant treatment protects against bleomycin - induced lung damage in rats 显示文摘 | A Serrano - Mollar D Closa | 2003 | British Joumal of Pharmacology2003，138，： | 1 |
| 12 | Ultimate Bearing Capacity of Rock Masses 显示文摘 | SERRANO A OLALLA C | 1994 | International Journal of Rock Mechanics and Mining Science1994，31，： | 1 |
| 13 | Trend Analysis of Monthly PrecipitationOver the Iberian Peninsula for the Period 1921-1995显示文摘 | Serrano V L Mateos V L Garcia J A | 1999 | Physics and Chemis-try of the Earth:B1999，24，2： | 1 |
| 14 | Nanocrystalline ZSM-5:A catalyst with high activity and selectivity for epoxide rearrangement reactions显示文摘 | SERRANO D P VAN GRIEKEN R MELERO J A | 2010 | Journal of Molecular Catalysis A:Chemical2010，318，12： | 1 |
| 15 | Nasal and bronchial inflammation after nasal allergen challenge: assessment using noninvasive methods显示文摘 | Serrano CD Valero A Bartra J | 2012 | J Investig Allergol Clin Immunol2012，22，5： | 1 |
| 16 | Wavelet Leadeas: A new method to estimate the multifractal singularity spectra 显示文摘 | Serrano E Figliola A | 2009 | Physica A2009，388，14： | 1 |
| 17 | Direct prediction of bioethanol yield in sugar beet pulp using Near Infrared Spectroscopy显示文摘 | C. Maga?a N. Nú?ez-Sánchez V.M. Fernández-Cabanás P. García A. Serrano D. Pérez-Marín J.M. Pemán E. Alcalde | 2011 | Bioresource Technology2011，，20： | 1 |
| 18 | Effect of ethylene concentration on quality parameters of fresh tomatoes stored using a carbon-heat hybrid ethylene scrubber显示文摘 | Domingo Martínez-Romero Fabián Guillén Salvador Castillo Pedro Javier Zapata Daniel Valero María Serrano | 2008 | Postharvest Biology and Technology2008，，2： | 1 |
| 19 | Beneficial effects of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta显示文摘 | Serrano M A Brites D Larena M G | 1998 | J Hepatol1998，28，： | 1 |
| 20 | Rich-club vs rich-multipolarization phenomena in weighted networks显示文摘 | Serrano M A | 2008 | Physical Review E2008，8，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员