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| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | Atmospheric aerosol in an urban aero-measurement of TSP and PM10 standards and pulmonary deposition assessments 显示文摘 | Berico M Luciani A Formignani M | 1997 | Atmospheric Environment1997，31，21： | 1 |
| 3 | Telomeric 22q13 deletions resulting from rings, simple deletions, and translocations: cytogenetic, molecular, and clinical analyses of 32 new observations显示文摘 | Luciani J J de Mas P Depetris D Mignon-Ravix C Bottani A Prieur M | 2003 | J Med Genet2003，40，9： | 1 |
| 4 | Phase separation and gelation of epoxy resin/hyperbranched polymer blends 显示文摘 | MEZZENGA R LUCIANI A MANSON J-A E P | 2002 | Polymer Engineering and Science2002，42，： | 1 |
| 5 | The Selli Level of the Gargano Promontory, Apulia, southern Italy: foraminiferal and calcareous nannofossil data显示文摘 | Cobianchi M Luciani V Menegatti A | 1999 | Cretaceous Re search1999，20，3： | 1 |
| 6 | Lymph node imaging: Basic principles显示文摘 | Luciani A Itti E Rahmouni A | 2006 | Eur J Radiol2006，58，3： | 1 |
| 7 | Les pseudolsions hpatiques 显示文摘 | Mathieu D Luciani A Achab A | 2001 | Gastroenterol Clin Biol2001，25，4： | 1 |
| 8 | Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women 显示文摘 | GOODSON W H LUCIANI M G SAYEED S A | 2011 | Carcinogenesis2011，32，11： | 1 |
| 9 | Clinical analysis of multiple primary malignancies in the elderly显示文摘 | Luciani A Ascione G Marussi D | 2009 | Med Oneol2009，26，1： | 1 |
| 10 | Global and local path planning in natural environment by physical modeling显示文摘 | Chanclou B Luciani A | 1996 | Intelligent Robotic and System ''96 IROS 96 Proceedings of the 1996 IEEE/RSJ International Conference on1996，3，： | 1 |
| 11 | Lymph node imaging: basic principles显示文摘 | Luciani A Itti E Rahmouni A | 2006 | Eur J Radiol2006，58，3： | 1 |
| 12 | Continuous bulk pro- cess for the production of high-impact polystyrene: recent de- velopments in modeling and control显示文摘 | Meira G R Luciani C V Estenoz D A | 2007 | Macromolecular Reac- tion Engineering2007，1，1： | 1 |
| 13 | Catheter-Related Upper Extremity Deep Venous Thrombosis in Cancer Patients:A Prospective Study Based on Doppler US显示文摘 | Luciani A Clement O Halimi P | 2001 | Radiology2001，220，3： | 1 |
| 14 | Simultaneous bilateral breast and high-resolution axillary MRI of patients with breast cancer: Preliminary results 显示文摘 | Luciani A Dao TH Lapeyre M | 2004 | A JR Am J Roentgenol2004，182，4： | 1 |
| 15 | Focal nodular hyperplasia of the liver in men:is presentation the same in men and women?显示文摘 | Luciani A Kobeiter H Maison P | 2002 | Gut2002，50，6： | 1 |
| 16 | Atmos- pheric aerosol in an urban areae measurement of TSP and PM10 standards a pulmonary deposition assessment 显示文摘 | BERICO M LUCIANI A FORMIGNANI M | 1997 | Atmospheric Environment1997，31，21： | 1 |
| 17 | Internal abdominal herniations 显示文摘 | Mathieu D Luciani A | 2004 | AJR2004，183，2： | 1 |
| 18 | Liver cirrhosis:in- travoxel incoherent motion MR imaging-Pilot study显示文摘 | Luciani A Vignaud A Cavet M | 2008 | Ra- diology2008，249，3： | 1 |
| 19 | Effect of proton pumpinhibitor pretreatment on resistance of solid tumors to cyto-toxic drugs显示文摘 | Luciani F Spada M De Milito A | 2004 | J Natl Cancer Inst2004，96，22： | 1 |
| 20 | Multiple primary maligngncies显示文摘 | Luciani A Bslducci L | 2001 | Semin Oncol2001，31，2： | 1 |
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