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    题名 作者 年代 出处 被引量
1Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz 2006Cytotherapy2006,,4:11
2Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement显示文摘M Dominici K Le Blanc I Mueller I Slaper-Cortenbach Fc Marini Ds Krause Rj Deans A Keating Dj Prockop Em Horwitz 2006Cytotherapy2006,,4:9
3连续冷却过程中的相变本构方程显示文摘如何有效地预测在不同工艺条件下材料的微观结构和力学性能,是许多钢铁公司非常关注的重要课题之一。以连续冷却过程中的自由能理论为基础,成功地开发出一套在连续冷却过程中统一的相变本构方程。该本构方程可用来预测钢材在不同的冷却速度下从奥氏体到铁素体、珠光体或贝氏体的开始转变点和结束转变点,同时还可用来预测各相转变的体积分数。利用优化算法通过缩小试验数据和预测数据之间的误差来确定本构方程中的材料常数,得出DINSAE5140钢种相变本构方程的模型参数,并且利用该相变本构方程对DINSAE5140钢种的相变过程进行详细地研究。研究结果表明,利用所开发的模型参数得出的预测连续冷却转变(Continuous cooling transformation,CCT)曲线和相变过程中各相的转变体积分数与试验数据非常一致,该统一的本构方程的建立为预测相变过程提供了一种有效的方法。阳代军 宁林新 林建国 DEAN T A 2009机械工程学报2009,45,2:4
4The spectrum of neuromyelitis optica显示文摘Dean M Wingerchuk Vanda A Lennon Claudia F Lucchinetti Sean J Pittock Brian G Weinshenker 2007Lancet Neurology2007,,9:3
5Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement显示文摘EM Horwitz K Le Blanc M Dominici I Mueller I Slaper-Cortenbach FC Marini RJ Deans DS Krause A Keating 2005Cytotherapy2005,,5:2
6通过模拟学习最大限度地提高物理治疗的临床实习成效(英文)显示文摘本文描述物理治疗专业和物理治疗入门级教育在中国康复医学教育中的演变,提倡以模拟学习技术(simulation-based learning,SBL)为临床实习生积累经验。与医学专业的学生一样,物理治疗专业学生的教育需要一个结构化的临床教育方案,以确保毕业时具备一定的临床专业能力。SBL多年以来一直是医学、工程以及航空专业的首选教学模式。在物理治疗专业培养方案中,SBL培养临床技能的教学模式已经出现。本文亦论述SBL在物理治疗专业入门级教育中的优势,尤其是使用模拟标准化患者作为核心临床教育内容,为学生进入临床实习做好准备。我们建议中国可以将SBL应用在物理治疗专业人才培养方案中,这能够最大限度地提高学生的临床实习经验。Alice Y M JONES Margot A SKINNER Elizabeth DEAN 2015康复学报2015,25,1:2
7Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage.Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda 2016World Journal of Gastroenterology2016,22,38:2
8Low potential for climatic stress adaptation in a rainforest drosophila species显示文摘Hoffmann A A Hallas R J Dean J A 2003Science2003,301,:2
9Effect of ethanol on pro-apoptotic mechanisms in polarizedhepatic cells显示文摘Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol- induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system.Benita L McVicker Dean J Tuma Carol A Casey 2007World Journal of Gastroenterology2007,13,37:2
10A review of the development of creep age forming: Experimentation, modelling and applications显示文摘Lihua Zhan Jianguo Lin T A Dean 2010International Journal of Machine Tools and Manufacture2010,,1:2
11Effect of Laminar Cooling on Phase Transformation Evolution in Hot Rolling Process显示文摘The effect of temperature variation owing to the cooling pattern(CP)on the microstructural evolution was investigated by establishing a thermomechanical coupled FE(finite element)model.A set of constitutive equations of phase transformation was implanted into the commercial FE solver MARC through the user defined subroutine CRPLAW,and the temperature field was calculated by another user defined subroutine FILM.The results show that the final microstructure is completely bainite phase for CP one,98% of bainite phase and 2% of ferrite phase for CP two,and 55% of bainite phase,35% of pearlite phase and 10% of ferrite phase for CP three.NING Lin-xin YANG Dai-jun J Lin T A Dean 2010Journal of Iron and Steel Research(International)2010,17,10:2
12p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘Dean J L Brook M Clark A R 1999J Biol Chen1999,274,:1
13Human resource management, manufacturing strategy, and firm performance 显示文摘Youndt M A Snell S A Dean J W Lepak D P 1996Academy of Management Journal1996,39,:1
14The Human ATP- Binding Cassette ( ABC ) Transporter Superfamily 显示文摘Dean M Rzhetsky A Allikmets R 2001GENOME RESEARCH2001,11,7:1
15Condensation heat transfer within horizontal tubes显示文摘Akers W W Deans H A Crosser O K 1959Chemical En- gineering Progress Symposium Series1959,55,29:1
16G Protein α Subunit Genes Control Growth, Development, and Pathogenicity of Magnaporthe grisea显示文摘LIU S H DEAN R A 1997Mol Plant-Microbe Interact1997,10,9:1
17Mesenchymal stem cells: biology and potential clinical uses显示文摘Deans R J Moseley A B 2000Exp Hematol2000,28,:1
18Clinical characteristics of peanut allergy显示文摘HOURIHANE J O KILBURN S A DEAN P 1997Clin Exp Allergy1997,27,6:1
19A method of uniform stratification of risk for evaluating the results of surgery in acquired adultheartdisease显示文摘Parsonnet V Dean D Bernstein A D 1989Circulation1989,79,62:1
20Modelling of springback in creepforming thick aluminum sheets 显示文摘Ho K C Lin J Dean T A 2004International Journal ofPlasticity2004,20,:1
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