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| 1 | The tumor-selective over-expression of the human Hsp 70 gene is attributed to the aberrant controls at both initiation and elongation levels of transcription显示文摘The tumor selective over-expression of the human Hsp70 gene has been well documented in human tumors,linked to the poor prognosis,being refractory to chemo-and radio-therapies as well as the advanced stage of tumorous lesions in particular.However,both the nature and details of aberrations in the control of the Hsp70 expression in tumor remain enigmatic.By comparing various upstream segments of the Hsp70 gene for each''s ability to drive the luciferase reporter genes in the context of the tumor cell lines varying in their p53 status and an immortal normal liver cell line,we demonstrated in a great detail the defects in the control mechanisms at the both initiation and elongation levels of transcription being instrumental to the tumor selective profile of its expression.Our data should not only offer new insights into our understanding of the tumor specific over-expression of the human Hsp70 gene,but also paved the way for the rational utilization of the tumor selective mechanism with the Hsp70 at the central stage fortargeting the therapeutic gene expression to human tumors. | LING CAI, JING DE ZHU,The State-key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 25/2200, Xie-tu Road, Shanghai 200032, China | 2003 | Cell Research2003，13，2： | 13 |
| 2 | ANALYSIS ON THE BEHAVIOR OF PRECIPITATES IN ULTRA-THIN HOT STRIP OF PLAIN LOW CARBON STEEL PRODUCED BY COMPACT STRIP PRODUCTION显示文摘This paper investigated the mechanism of precipitation and its influence upon prop-erties of ultra-thin hot strips of low carbon steel produced by CSP techniques usingexperiment and thermodynamics theory. The experimental results show that thereare lots of fine and dispersive precipitates in microstructures. By analysis, most ofaluminum nitrides are in grains, while coexisted precipitates of MnS are along grainboundaries. Coexisted precipitates compose cation-vacancy type oxides such as Al2O3in the core, while MnS is at the fringe of surface. The precipitation behavior of AlNand MnS in the hot strip is studied by thermodynamic calculation. At last, implica-tions between strengthening effect and techniques are analyzed using obtained solubilityproducts. | H.Yu,Y.L.Kang,H.B.Dong,D.L.Liu and J.FuUniversity of Science and Technology Beijing, Beijing 100083, China Manuscript received 10 October 2001 in revised form 25 January 2002 | 2002 | Acta Metallurgica Sinica(English Letters)2002，15，4： | 11 |
| 3 | 湖北省红安—大悟地区 原中—新元古代地层中发现古生代化石显示文摘 | 湖北省地质调查院1:25万麻城幅项目组 | 2001 | 中国地质2001，28，11： | 7 |
| 4 | The promoter analysis of the human C17orf25 gene, a novel chromosome 17pl3.3 gene显示文摘The human C17orf25 gene (Accession No. AF177342) is one of thirteen genes cloned from a region displaying a high score of loss of heterozygosity within chromosome 17p13.3 in human hepatocellular car-cinoma in China[l]. To unveil the underlying mechanisms for the transcription regulation of this gene and understand its implication to the hepatocellular carcinogenesis, we looked into the relevant aspects by both bioinformatic and experimental executions. We found: 1, The abundant expression of the C17orf25 gene was evident in all the cell lines and tissue samples tested, showing little hepatoma-selectivity; 2, Its tran-scription starts at a single site, locating at -60 from the translation initiation codon; 3, A 58 bp fragment containing the transcription start, extending from -112 to -55, represents the minimal promoter; 4, The consensus sequence within this fragment recognized by SP1 contributes predominantly to the activity of the minimal promoter; 5, The bioinformatic analysis suggests that the C17ort25 gene may encode a protein in the family of the glyoxalase. Our data has provided some deep insight into both function and regulation of the C17orf25 gene in the context of the normal liver and hepatocellular carcinoma. | JIAN YING GUO, JIAN XU, DA QIN MAO, LI LI FU, JIAN REN GU, JING DE ZHUThe State-Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ln 2200/25, Xie-Tu Road, Shanghai 200032, China | 2002 | Cell Research2002，12，5： | 7 |
| 5 | InteractionoftheKuroshiowaterandshelfwaterintheTsushimaCurrentregioninsummer显示文摘InteractionoftheKuroshiowaterandshelfwaterintheTsushimaCurrentregioninsummerGuoBinghuo,1Heung-JaeLie2andJaeHakLee2(ReceivedSe... | Guo Binghuo Heung-Jae Lie and Jae Hak Lee2( Received September 20, 1997 accepted October 25, 1997) | 1998 | Acta Oceanologica Sinica1998，17，3： | 6 |
| 6 | Single rub-impacting periodic motions of a rigid constrained rotor system显示文摘This paper discusses the existence of single rub-impacting period-n motions for a kind of rotor systems with rigid constraints. The ranges of parameters for period-2 motions are also given. An example of this method is given. | Qunhong LI and Qishao LU (School of Science, Beijing University of Aeronautics and Astronautics, Beijing 100082, China) (Received September 25, 2000) | 2000 | Communications in Nonlinear Science and Numerical Simulation2000，5，4： | 2 |
| 7 | 山西省宁武—静乐盆地早侏罗世永定庄组的确定及恐龙化石的发现显示文摘 | 山西省地质调查院1:25万岢岚县幅项目组 | 2001 | 中国地质2001，28，11： | 1 |
| 8 | Energy a CCHP system with 显示文摘 | Kong X Q Wang R Z optimization model for available gas turbines Engineering 2005 25(2): Huang X H | 2005 | Applied Thermal2005，，： | 1 |
| 9 | Sternocleidomastoidpseudotumorofinfantsandcongenitalmusculartorticollis:fine-structureresearch显示文摘 | 〔25〕TangS LinZ QuanX etal | 1998 | JPediatrOrtop1998，18，： | 1 |
| 10 | 《大正新修大藏经》显示文摘 | 《大智度论》 25册 | | 0，，： | 1 |
| 11 | MITI PROGRAM ON HIGH TEMPERATURE INTERMETALLICS显示文摘An eight year national program aiming at the development of high temperature intermetallics was started by the Agency of Industrial Science and Technology of the Ministry of International Trade and Industry (AIST MITI) in 1989 and almost successfully ended in 1997. This national program with emphasis on basic aspects of the properties and processing of high temperature intermetallics, Ti Al and Nb Al, have given a considerable impetus to intermetallics research in Japan. This is an overview of the results of the program and implications of the program for the future development of high temperature intermetallics compounds for structural applications. Alloy design, evaluation of fundamental mechanical properties, fabrication processing and surface modification have been investigated using these two alloy systems. Based on the obtained results, the concept of alloy design was established, and new technologies, were developed for metal injection moding, casting, rheocasting, sheet casting and rolling, superplastic forming, heat treatment, melting and investment casting, gas atomization, direct rolling of alloyed powders, near net shaping by HIPing alloyed powders and oxidation resistant surface coating. Some of suggested intermetallics alloys are expected to be basics for ultra high temperature structural materials in the next generation because of the extremely high strengths at high temperature, 1 100 ℃ and 1 800 ℃, beyond conventional Ni base superalloys. | Makoto Tomita and Yusei Noguchi R&D Institute of Metals and Composites for Future Industries (RIMCOF), 25 2, Toranomon 3 Chome, Minato Ku, 105 0001, Japan | 1999 | 中国有色金属学会会刊:英文版1999，9，S1： | 1 |
| 12 | “当代国际政治背景下的国家主权问题”,转引自王逸舟,《欧洲》显示文摘 | 《百科全书》(国际版)第25卷 第6期 | 1978 | 欧洲研究1978，，6： | 1 |
| 13 | 显示文摘 | 徐岩.? 关于加强高校安全教育的几点思考(J)华章. 2013 (25) | 2013 | 华章2013，，25： | 1 |
| 14 | Apoptoticphotoreceptercelldeathaftertraumaticretinaldetachmentinhumans(seecomments)显示文摘 | 25,ChangCJ LaiWW EdwardDP etal | 1995 | ArchOphthalmol1995，113，7： | 1 |
| 15 | 显示文摘 | 宋红燕.? 新课程标准下高中数学“分层次教学”实践(J)科教新报(教育科研). 2010 (25) | 2010 | 科教新报(教育科研)2010，，25： | 1 |
| 16 | 8-Gb/s OFDM transmission over 4160-kin SSMF 显示文摘 | S L Jansen I Morita T C W Schenk : Coherent optical 25 | 2008 | J Lightwave Technol2008，26，1： | 1 |
| 17 | The synthesis of C-silyl-substi- 显示文摘 | FRANCOISE D ODILE L tuted aziridine derivatives 25 -28 | 1978 | J Org Chem1978，156，2： | 1 |
| 18 | 观察恒河猴隐睾(热刺激)模型中睾丸细胞细胞外信号调节激酶1和2(ERK1/2)的激活 | Xue-Sen Zhang~+ Zhi-Hong Zhang~+ Shu-Hua Guo Wei Yang,Zhu-Qiang Zhang Jin-Xiang Yuan Xuan Jin Zhao-Yuan Hu Yi-Xun Liu State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,25 Bei Si Huan Road West,Beijing 100081,China | 2006 | Asian Journal of Andrology2006，8，A03： | 1 |
| 19 | 显示文摘 | 吕志强 冉小亚 吴勇 龚坚 杨纪弘.? 浅析医院PACS建设的必要性及问题的探讨(J)华章. 2011 (25) | 2011 | 华章2011，，： | 1 |
| 20 | 显示文摘 | 涂平菊.? 新课改后初高中化学教学衔接(J)科教新报(教育科研). 2011 (25) | 2011 | 科教新报(教育科研)2011，，25： | 1 |
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