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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | 我国胆石病十年来的变迁显示文摘作者报道了由全国胆道外科学组组织的来自7个省市、33所医院3911例胆结石手术病例的第二次全国临床调查资料并与十年前首次调查的结果(中华外科杂志1987,25:321~329)比较。调查证实:胆石病仍是我国普外临床的多发病,约占同时期住院患者的11.5%;多见于50岁以上的女性;女:男约2.57:1。约80%的单一部位结石分布于胆囊,以胆固醇类结石为主;而以胆色素类为主的胆管结石仅占10%。与十年前相比,胆囊:胆管结石从1.5:1上升至7.36:1;胆固醇:胆色素结石从1.4:1升至3.4:1。调查还发现:上述关于结石类型及结石部位上的变化与近十年来胆道蛔虫及胆道感染率的显著下降及饮食结构的变化有关。 | Zhu Xueguang Zhang Shengduo HuangZhiqiang et al. People′s Hospital,Beijing Medical U-niversity,Beijing100044. | 1995 | 中华外科杂志1995，33，11： | 155 |
| 3 | 血管疾病中叶酸和B族维生素的使用不能降低高半胱氨酸浓度显示文摘 | Lonn E Yusuf S Arnold MJ 菅鑫妍 | 2006 | 中国处方药2006，5，6： | 137 |
| 4 | 全氟辛烷磺酰基化合物(PFOS)的污染现状与研究趋势显示文摘全氟辛烷磺酰基化合物(PFOS,perfluorooctane sulfonate)所造成的污染已经逐渐成为全球性环境问题,发达国家非常重视PFOS等全氟化合物的研究,已经成为持久性有机污染物研究的又一个热点。本文对目前PFOS研究的现状、进展,以及存在的问题做了简要回顾,并且对今后研究重点做了预测,希望对PFOS研究者提供参考。 | 郭睿 蔡亚岐 江桂斌 K S Paul Lam | 2006 | 化学进展2006，18，6： | 92 |
| 5 | 急性肾损伤诊断与分类专家共识显示文摘近几十来.临床和基础的研究工作者们针对急性肾功能衰竭(ARF)进行了广泛的研究,尽管我们在该疾病的生理和发病机制方面都取得了长足的进步,但如何将这些知识用于临床,改进ARF患者预后方面的工作却做得十分有限。ARF是由多种病因导致、可发生在各种临床情况之下(儿童或成人、门诊或住院、ICU或非ICU患者)的一种复杂的肾功能紊乱,其临床表现既可以是血肌酐水平的轻微升高,也可以是无尿性肾功能衰竭。 | RL Mehta JA Kellum S Shah B Molitoris C Ronco D Warnock A Levin 王欣 | 2006 | 中华肾脏病杂志2006，22，11： | 348 |
| 6 | 世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染显示文摘我非常高兴向大家推荐这份发展中国家幽门螺杆菌(H.priori)临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG Fock KM Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖 丛衍群 戴宁 | 2007 | 胃肠病学2007，12，1： | 85 |
| 7 | 2006年第二次全国残疾人抽样调查主要数据公报显示文摘 | Leading Group of the Second China National Sample Survey on Disability, National Bureau of Statistics of the People’s Republic of China | 2006 | 中国康复理论与实践2006，12，12： | 152 |
| 8 | 我国面临快速增长的终末期肾病治疗负担显示文摘目的报告2008年我国终末期肾脏病维持性透析患病率和发病率,并估计未来维持性透析的趋势。方法中国医院协会血液净化中心管理分会制定调查表,以透析登记软件及纸质版形式下发至各省、自治区和直辖市的血液净化中心管理分会/血液净化质量控制中心,收集各透析室的数据,包括2007年底和2008年底患者数量,以及2008年新进入透析的患者数量;患者的性别和年龄构成;导致终末期肾脏病(ESRD)的原因以及所有死亡患者的原因。分析2007和2008年底ESRD的点患病率、2008年ESRD发病率、ESRD病因以及死亡原因构成。结果全国31个省、自治区和直辖市中,27个应答。2007年底,共报告65074例ESRD患者,点患病率为每百万人口51.7;2008年底患者数增至102863例,点患病率为每百万人口79.1,患病率增长52.9%。2008年ESRD新患者数为45423例,发病率每百万人口36.1。ESRD的病因依次为肾小球肾炎(45%)、糖尿病(19%)、高血压(13%)、多囊肾病(2%)和其他或未知(20%)。ESRD主要死亡原因是心血管疾病(31%)、中风(20.3%)、感染(19.9%)和其他(28.8%)。结论虽然我国ESRD的患病率显著低于其他亚洲国家和地区,但发病率极高,未来几年患病率也将快速增加,从而增加我国ESRD的治疗负担。 | Li Zuo M.D.1 and Mei Wang M.D.2 for Chinese Society of Blood Purification Institute of Nephrology,Peking University First 1 Hospital Institute of Nephrology,Peking University People’s Hospital 2 | 2010 | 中国血液净化2010，，1： | 145 |
| 9 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 10 | NF-KB in immunobiology显示文摘 | Matthew S Hayden Sankar Ghosh | 2011 | Cell Research2011，21，2： | 101 |
| 11 | 原发性肝癌诊疗规范(2011年版)显示文摘一、概述原发性肝癌(primarylivercancer,PLC,以下简称肝癌)是常见恶性肿瘤。由于起病隐匿,早期没有症状或症状不明显,进展迅速,确诊时大多数患者已经达到局部晚期或发生远处转移,治疗困难,预后很差,如果仅采取支持对症治疗,自然生存时问很短,严重地威胁人民群众的身体健康和生命安全。 | Ministry of Health of the People’s Republic of China | 2011 | 临床肝胆病杂志2011，27，11： | 491 |
| 12 | 官厅水库和永定河沉积物中多氯朕苯和有机氯农药的污染显示文摘利用气相色谱-电子捕获检测(GC-ECD)方法对官厅水库-永定河流域沉积物中26种多氯联苯(PCBs)同系物和13种有机氯农药进行了分析测定,在4个采样点均检出多氯联苯和部分有机氯农药.其中PCBs和有机氯农药总量的最高点均出现在永定河下游的三家店,分别为9.7ng·g-1和26.7ng·g-1,按照国际关于沉积物质量的同类研究结果,判定为轻度污染水平.HCH最高仅为4.50ng·g-1,属轻度污染,DDT浓度以八号桥和三家店样点最高,分别为23.2ng·g-1和26.7ng·g-1,属中度污染.有机氯农药总量分布为三家店>八号桥>官厅大坝>雁翅,表明永定河下游多氯联苯和有机氯农药不仅来自官厅上游,也来自下游地区. | 马梅 王子健 Anders Sdergren | 2001 | 环境化学2001，20，3： | 85 |
| 13 | 佳木斯地块片麻状花岗岩的锆石离子探针U-Pb年龄显示文摘我国东北地区佳木斯地块分布有大量的花岗质岩石 ,这些花岗岩可分为两个大的类型 ,其一为基底花岗片麻岩类 ,岩石曾经历过 5 0 0 Ma左右的角闪岩相 -麻粒岩相变质作用的改造 ,并具有与麻山群变质岩系相同或一致的片麻理构造。其二为片麻状花岗岩类 ,片麻理发育程度不等 ,岩石显示明显的岩浆结晶结构 ,不具有任何后期变质作用叠加的痕迹。传统认为片麻状花岗岩形成于新元古代 ,但本文通过高精度的锆石离子探针 U- Pb测年表明 ,这些花岗岩主要形成于 2 70~ 2 5 4 Ma的晚古生代 ,且部分岩石中含有较老的锆石颗粒或残留 ,表明这些花岗岩主要来源于基底岩石的部分熔融。测定岩石的矿物组成和化学成分特点暗示 。 | 吴福元 S W ILDE 孙德有 | 2001 | 岩石学报2001，17，3： | 131 |
| 14 | 中国进展期乳腺癌共识指南(CABC 2015)显示文摘在2013年出版的《首届中国进展期乳腺癌共识指南(草案)》(CABC1)的基础上,本指南进一步更新了进展期乳腺癌诊疗过程的一般原则、相关的定义、疗效的评估、不良反应的管理及不同治疗方法的基本策略等内容;专家组系统阅读国内外各种关于进展期乳腺癌的临床研究(包括回顾性的资料分析),整理并总结了各种相关指南,召开会议组织专家进行了多次讨论,将在循证医学基础上达成的专家共识整理成文,为从事乳腺癌专业的医生,尤其是以治疗进展期乳腺癌为主要专业的医生,提供参考。 | China Medical Women′s Association of Clinical Oncology | 2015 | 癌症进展2015，13，3： | 84 |
| 15 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 16 | 手足口病诊疗指南(2018年版)显示文摘手足口病(hand foot and mouth disease,HFMD)是由肠道病毒(enterovirus,EV)感染引起的一种儿童常见传染病,5岁以下儿童多发。手足口病是全球性疾病,我国各地全年均有发生,发病率为37.01/10万-205.06/10万,近年报告病死率在6.46/10万-51.00/10万之间。为进一步规范和加强手足口病的临床管理。 | National Health Commission of the People′s Republic of China | 2018 | 中国病毒病杂志2018，8，5： | 162 |
| 17 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 18 | METAMORPHIC MECHANISMSAND THEIR CONFIGURATION MODELS显示文摘The concept of metamorphic mechanisms is presented, configuration models and configuration transformations relating to a set of new matrix operations are discussed and proposed. The configuration of a metamorphic mechanism reflects the connectivity change in the mechanism during motions which results in mobility change and presents the characteristics of the mechanism which is discussed in various applications particularly in decorative artifacts. The characteristics is further investigated with mobility analysis. | Dai Jiansheng (Department of Mechanical Engineering, School of Physical Sciences and Engineering, King’s College, University of London,Strand,London WC2R 2LS, United kingdom) Zhang Qixian (Robotics Research Institute,Beijing University of Aeronautics and | 2000 | Chinese Journal of Mechanical Engineering2000，13，3： | 61 |
| 19 | Magnetostratigraphy of the late Cenozoic Laojunmiao anticline in the northern Qilian Mountains and its implications for the northern Tibetan Plateau uplift显示文摘Cenozoic sediments in the foreland basin--Jiuquan Basin in west Hexi Corridor recorded tectonic uplift information of the Qilian Mountains. High resolution paleomagnetic dating of the Laojunmiao (LJM) section across the central LJM anticline in the southern Jiuquan Basin reveals ages of the Getanggou Member, Niugetao Member in the Shulehe Formation, the Yumen Conglomerate, Jiuquan Conglomerate and Gobi Formation at >13-8.3 Ma, 8.3-4.9 Ma, 3.66-0.93 Ma, 0.84-0.14 Ma and 0.14-0 Ma, respectively. Sedimentary evolution study suggests that the Qilian Mountains should begin to rise gradually since ~8-6.6 Ma, accompanied by sedimentary environments changing from lacustrine mudstones-sandstones to alluvial conglomerates. Rapid uplift of the Qilian Mountains began at ~3.66 Ma, followed by a series of stepwise or intermittent intensive uplifts at about <1.8-1.23 Ma, 0.93-0.84 Ma and 0.14 Ma, which finally resulted in the present high Qilian Mountains. | FANG Xiaomin1,2, ZHAO Zhijun3,2, LI Jijun2, YAN Maodu2, PAN Baotian2, SONG Chunhui2 & DAI Shuang2 1. Institute of Tibetan Plateau Research, Chinese Academy of Sciences, Beijing 100085, China 2. Key Laboratory of Western China’s Environmental Systems, Ministry of Education & College of Resources and Environment, Lanzhou University, Lanzhou 730000, China 3. College of Geography, Nanjing Normal University, Nanjing 210097, China | 2005 | Science China Earth Sciences2005，48，7： | 61 |
| 20 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
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