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    题名 作者 年代 出处 被引量
1Primary liver cancer: Worldwide incidence and trends显示文摘F.Xavier Bosch Josepa Ribes Mireia Díaz Ramon Cléries 2004Gastroenterology2004,,5:10
2Epidemiology of Hepatocellular Carcinoma显示文摘F. Xavier Bosch Josepa Ribes Ramon Cléries Mireia Díaz 2005Clinics in Liver Disease2005,,2:2
3Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring显示文摘Martínez-Téllez RI Hernández-Torres E Gamboa C 2009Synapse2009,63,9:1
4Influence of thickness on the properties of hydroxyapatite coatings deposited by KrF laser ablation显示文摘Fernández-Pradas J M Clèries L Martínez E 2001Biomaterials2001,22,:1
5Influence of the interface layer on the adhesion of pulsed laser deposited hydroxyapatite coatings on titanium alloy显示文摘Fernández-Pradas J M García-Cuenca M V Clèries L 2002Applied Surface Science2002,195,:1
6Does self-care agency change between hospital admission and discharge? An Orem-based investigation显示文摘Zrínyi M Zékányné RI 2007Int Nurs Rev2007,54,3:1
7Thirdgenome size category of avian paramyxovirus serotype 1(New-castle disease virus)and evolutionary implications显示文摘Alíz Czeglédi Dorina Ujvári Eszter Somogyi 2006VirusResearch2006,120,:1
8Biochemical bone markers,bone mineral content,and bone miner-al density in rats with experimental nephrotic syndrome显示文摘Sierra RI Specker BL Jiménez F Cruz C Pedraza-ChaverríJ 1997RenFail1997,19,3:1
9Electron states and electron Raman scattering in semiconductor double cylindrical quantum well wire显示文摘The differential cross section for an electron Raman scattering process in a semiconductor GaAs/AlGaAs double quantum well wire is calculated,and expressions for the electronic states are presented.The system is modeled by considering T = 0 K and also with a single parabolic conduction band,which is split into a subband system due to the confinement.The gain and differential cross-section for an electron Raman scattering process are obtained.In addition,the emission spectra for several scattering configurations are discussed,and interpretations of the singularities found in the spectra are given.The electron Raman scattering studied here can be used to provide direct information about the efficiency of the lasers.M Munguía-Rodríguez Ri Betancourt-Riera Re Betancourt-Riera R Riera J M Nieto Jalil 2016Chinese Physics B2016,25,11:0
10Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications显示文摘Alíz Czeglédi Dorina Ujvári Eszter Somogyi Enik? Wehmann Ortrud Werner Béla Lomniczi 2006Virus Research2006,,1:2
11A comparison of process performance during the anaerobic mono-and co-digestion of slaughterhouse waste through different operational modes显示文摘The use of consecutive feeding was applied to investigate the response of the microbial biomass to a second addition of substrates in terms of biodegradation using batch tests as a promising alternative to predict the behavior of the process. Anaerobic digestion(AD) of the slaughterhouse waste(SB) and its co-digestion with manure(M), various crops(VC), and municipal solid waste were evaluated. The results were then correlated to previous findings obtained by the authors for similar mixtures in batch and semi-continuous operation modes. AD of the SB failed showing total inhibition after a second feeding. Co-digestion of the SB + M showed a significant improvement for all of the response variables investigated after the second feeding, while co-digestion of the SB + VC resulted in a decline in all of these response variables. Similar patterns were previously detected, during both the batch and the semi-continuous modes.Jhosané Pagés-Díaz Ileana Pereda-Reyes Jose Luis Sanz Magnus Lundin Mohammad J.Taherzadeh Ilona Sárvári Horváth 2018Journal of Environmental Sciences2018,30,2:0
12Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors显示文摘Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support methods.Digital drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted agents.DDA has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical trial.The aim of this study was to evaluate the utility of DDA in pediatric oncology.Methods Between 2017 and 2020,103 high-risk pediatric cancer patients(<21 years)were involved in our precision oncology program,and samples from 100 patients were eligible for further analysis.Tissue or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision support.Finally,a molecular tumor board(MTB)evaluated the results to provide therapy recommendations.Results Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing results.DDA identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug resistance.Actionability reached 88%(29/33)by 2020 due to the continuous updates of the evidence database.MTB approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed therapies.Filtering of WES results for targeted panels missed important mutations affecting therapy selection.Conclusions DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine care of high-risk pediatric cancers.Knowledgebase updates enable automatic interpretation of a continuously expanding gene set,a“virtual”panel,filtered out from genome-wide analysis to always maximize the performance of precision treatment planning.Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták 2023World Journal of Pediatrics2023,19,10:0
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